Effect of Angelica sinensis Polysaccharides on Osteoarthritis In Vivo and In Vitro: A Possible Mechanism to Promote Proteoglycans Synthesis
Figure 1
Effects of Angelica sinensis polysaccharides (APS-3c) on histological changes in cartilage as assessed by haematoxylin-eosin staining ((a), (b), (c), (d), (e) and (f), original magnification ×200) and Safranin O staining ((g), (h), (i), (j), (k) and (l), original magnification ×200) on rat osteoarthritis (OA) induced by papain. ((a) and (g)) Normal control group; ((b) and (h)) APS-3c control group: rats treated with 0.05% APS-3c; ((c) and (i)) OA model control group: papain-induced OA rats treated with sterile saline; ((d) and (j)) OA rats treated with 0.01% APS-3c; ((e) and (k)) OA rats treated with 0.025% APS-3c; ((f) and (l)) OA rats treated with 0.05% APS-3c every 5 days for 5 weeks. (m) Mankin score. Values represent Mean ± SEM of eight different simples. versus normal control group, versus OA model control group.
