Postischemic Long-Term Treatment with Qiangli Tianma Duzhong Capsule Improves Brain Functional Recovery via the Improvement of Hemorrheology and the Inhibition of Platelet Aggregation in a Rat Model of Focal Cerebral Ischemia

Figure 7

Long-term treatment with TMDZ inhibits ADP- or thrombin-induced platelet aggregation in ischemic stroke rats. Animals underwent 2 h MCAO and reperfusion and received either an oral administration of TMDZ or vehicle (distilled water) at 2 h MCAO, 4 h reperfusion and every day later for 28 days, and then the blood was obtained and the platelet aggregation induced by ADP or thrombin was detected. (a) and (c): representative curve of platelet aggregation induced by ADP (a) or thrombin (c). (b) and (d): quantitative analysis of changes in the platelet aggregation from 10 independent experiments of (a) and (c), respectively. Values shown are mean ± S.D., 𝑛=10. Statistical analysis was carried out with one-way ANOVA followed by a post hoc Tukey test. ^#𝑃<0.05 and ^##𝑃<0.01 versus sham-operated group (Sham); **𝑃<0.01 versus ischemia-reperfusion control group (IR Control).