Predicting In Silico Which Mixtures of the Natural Products of Plants Might Most Effectively Kill Human Leukemia Cells?

Table 1

Bioassay targets are confirmed as AML active proteins by literature searches and associated binding proteins are predicted by Ontomine.

S. no	Ontomine predicted; bioassays	Confidence level	Compound(s)	Reference; no
1	Guanine nucleotide binding protein, alpha activating; polypeptide-O	Medium	Honokiol	[13]
		Low	Cholecalciferol; Limonene; Retinyl palmitate
2	Multidrug resistance protein 1	Low	Mevinolin; Limonene; Resveratrol; Chrysin	[14]
3	Myeloid or lymphoid or mixed-lineage leukaemia protein	High	Aloe emodin; Mevinolin	[15]
		Low	Barbaloin; Limonene; Retinyl palmitate Cholecalciferol; Chrysin; L-Ascorbic acid 6-palmitate
4	Runt-related transcription factor 1 isoform AML1c	High	Chrysin	[16]
		Medium	Honokiol
		Low	Barbaloin; Mevinolin; Limonene; L-Ascorbic acid 6-palmitate