Tetrandrine Inhibits the Wnt/β-Catenin Signalling Pathway and Alleviates Osteoarthritis: An In Vitro and In Vivo Study
Figure 3
Effects of Tet on the expression of MMP-1, MMP-3, MMP-13, TIMP-1, and β-catenin in vivo experiment on cartilage in (a). The Tet and OA groups were treated with ACLT, and only the Tet groupwasgiven treatment of Tet (20 mg/L) for 6 weeks after surgery. Rabbits were sacrificed after last injection in articular cavity. Rabbits receive the sham-operation regarding as the Normal group. Representative pictures of macroscopic observations in (b) and Safranin O staining are shown in (c).
