Inclusion Complex of Zerumbone with Hydroxypropyl-<b><i>β</i></b>-Cyclodextrin Induces Apoptosis in Liver Hepatocellular HepG2 Cells via Caspase 8/BID Cleavage Switch and Modulating Bcl2/Bax Ratio

<table>Quantitative analysis of ZER-HP<i>β</i>CD inclusion complex mediated apoptosis parameter. Changes in (a) total nuclear intensity, (b) cell permeability, (c) mitochondrial membrane potential, and (d) cytochrome c localization were all measured simultaneously in HepG2 treated cells. Treatment with ZER-HP<i>β</i>CD inclusion complex showing statistically significant cell loss (data not shown), increased total nuclear intensity, increased cell permeability, loss of mitochondrial membrane potential, and cytochrome c release from the mitochondria with good <svg height="11.175" id="M37" style="vertical-align:-0.0pt" version="1.1" viewbox="0 0 10.9375 11.175" width="10.9375" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> values. Each experiment was performed at least two times. <svg height="13.95" id="M38" style="vertical-align:-0.16379pt" version="1.1" viewbox="0 0 68.949997 13.95" width="68.949997" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>) compared with control.</table>

Evidence-Based Complementary and Alternative Medicine

fig8

Figure 8

Figure 8: Inclusion Complex of Zerumbone with Hydroxypropyl-<b><i>β</i></b>-Cyclodextrin Induces Apoptosis in Liver Hepatocellular HepG2 Cells via Caspase 8/BID Cleavage Switch and Modulating Bcl2/Bax Ratio 

Figure 8 | Inclusion Complex of Zerumbone with Hydroxypropyl-β-Cyclodextrin Induces Apoptosis in Liver Hepatocellular HepG2 Cells via Caspase 8/BID Cleavage Switch and Modulating Bcl2/Bax Ratio 