Inclusion Complex of Zerumbone with Hydroxypropyl-β-Cyclodextrin Induces Apoptosis in Liver Hepatocellular HepG2 Cells via Caspase 8/BID Cleavage Switch and Modulating Bcl2/Bax Ratio

Table 1

Cytotoxicity of ZER-HP𝛽CD inclusion complex on different cancer and normal cells in vitro.

Cell line	Origin of cells	IC50 (𝜇g/mL)
HepG2	Liver hepatocellular cells	11.43±0.31
MCF-7	Oestrogen receptor-positive breast adenocarcinoma cells	15.32±0.61
MDA-MB-231	Oestrogen receptor-negative breast adenocarcinoma cells	17.20±0.17
CEMss	T-acute lymphoblastic leukemia	9.13±0.38
HeLa	Cervical cancer cells	14.47±0.26
WRL-68	Normal hepatic cell line	>30

IC₅₀ values were obtained from MTT assay. Data are reported as means ± SD for measurements in triplicate.