Integration of Different “-omics” Technologies Identifies Inhibition of the IGF1R-Akt-mTOR Signaling Cascade Involved in the Cytotoxic Effect of Shikonin against Leukemia Cells
Figure 3
Complementarity of various “-omics” technologies provides a system-level understanding of shikonin’s effects in U937 cells. (a) Comparison analysis of molecular and cellular functions affected by shikonin in three “-omics” assays. The bar graph displays only functions disturbed in all three assays. Right-tailed Fisher’s exact test was used to calculate a value determining the probability that each biological function assigned to the datasets is due to chance alone. (b) Overlapping signaling pathways deregulated after shikonin treatment. Numbers of identical molecules deregulated in overlapping pathways are shown.
