The Cardioprotective Effects of Citric Acid and L-Malic Acid on Myocardial Ischemia/Reperfusion Injury

Table 1

The effect of citric acid on myocardial ischemia/reperfusion injury in rats (𝑥±𝑠, n = 10).

Groups	Dosage (mg/kg)	Infarction of the ventricle (%)	Infarction of the heart (%)	Infarction area (mm^2)	Infarction weight (g)
Sham	—	0.00±0.00	0.00±0.00	0.00±0.00	0.000±0.000
Model control	—	17.30±3.58^##	11.98±2.20^##	49.75±9.14^##	0.086±0.017^##
Diltiazem	16	8.23±2.50^∗∗	5.33±1.11^∗∗	21.90±4.78^∗∗	0.038±0.007^∗∗
Clopidogrel	13.5	11.35±2.71^∗∗	8.52±1.77^∗∗	35.17±9.74^∗∗	0.064±0.015^∗
Citric acid	500	12.16±4.27^∗∗	8.80±3.41^∗∗	36.18±15.23^∗∗	0.064±0.026^∗
	250	11.80±3.67^∗∗	8.83±3.09^∗∗	33.97±10.99^∗∗	0.063±0.022^∗∗

^##𝑃<0.01 versus sham, **𝑃<0.01, *𝑃<0.05 versus model control.