The Cardioprotective Effects of Citric Acid and L-Malic Acid on Myocardial Ischemia/Reperfusion Injury

Table 2

The effect of L-malic acid on myocardial ischemia/reperfusion injury in rats (𝑥±𝑠, 𝑛=10).

Groups	Dosage (mg/kg)	Infarction of the ventricle (%)	Infarction of the heart (%)	Infarction area (mm^2)	Infarction weight (g)
Sham	—	0.00±0.00	0.00±0.00	0.00±0.00	0.000±0.000
Model control	—	9.03±3.32^##	6.00±1.67^##	32.01±11.84^##	0.051±0.014^##
Diltiazem	16	6.86±1.76^∗∗	4.68±1.39^∗	25.11±6.48^∗	0.041±0.012^∗
Clopidogrel	13.5	6.51±1.58^∗∗	4.75±1.19^∗	23.67±5.46^∗	0.038±0.010^∗
L-malic acid	500	6.71±1.23^∗∗	4.98±0.92	25.37±4.55^∗	0.043±0.009
	250	6.22±1.15^∗∗	4.48±0.93^∗∗	22.70±4.26^∗∗	0.036±0.007^∗∗

^##𝑃<0.01 versus sham, **𝑃<0.01, *𝑃<0.05 versus model control.