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Evidence-Based Complementary and Alternative Medicine
Volume 2013 (2013), Article ID 824120, 10 pages
Research Article

Administration of Glucosylceramide Ameliorated the Memory Impairment in Aged Mice

1Department of Neuroscience and TIDRC, School of Medicine, Ewha Womans University, Seoul 158-710, Republic of Korea
2Institute of Life Science Research, Rexgene Biotech, Ochang, Chungbuk 363-883, Republic of Korea
3Advanced Institutes of Convergence Technology, Doosan Corporation, Glonet BG Biotech Division, Suwon, Gyeonggi-Do 443-270, Republic of Korea

Received 23 October 2012; Accepted 6 March 2013

Academic Editor: Seung-Heon Hong

Copyright © 2013 Yeonju Lee et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The function and the role of glucosylceramide have not been well studied in the central nervous system. This study was aimed to investigate the possible roles of glucosylceramide in memory function in aged mice. Glucosylceramide (50 mg/kg, p.o.) showed memory enhancing activity after 3-month treatment in the aged mice (C56BL/6, 18–20 months old) through Y-maze, novel objective test, and Morris water maze test. Long-term treatment of glucosylceramide decreased the expression of iNOS and COX-2 in the brain of aged mice. The LPS-induced mRNA level of iNOS, COX-2, IL-1β, and TNF-α was reduced by the acute treatment with glucosylceramide in adult mice. These results suggest that glucosylceramide plays an important role in anti-inflammatory and memory enhancement, and it could be a potential new therapeutic agent for the treatment of neurodegenerative diseases such as Alzheimer’s disease.