The Evaluation of CP-001 (a Standardized Herbal Mixture of Houttuynia cordata, Rehmannia glutinosa, Betula platyphylla, and Rubus coreanus) for Cytochrome P450-Related Herb-Drug Interactions

Table 3

The effects of CP-001 on the CYP enzyme activities with preincubation.

P450 isozyme	Remaining activities (% of control)					IC50
	CP-001 (μg/mL)
	1	3	10	30	100
CYP1A2	111.4	98.8	79.3	83.5	70.6	>100
CYP2A6	116.1	106.8	104.9	101.5	96.9	>100
CYP2D6	107.3	109.6	129.2	109.3	98.7	>100
CYP2C9	83.7	96.8	75.5	76.4	69.8	>100
CYP2C19	117.5	109.7	106.3	94.2	75.1	>100
CYP3A4	111.6	109.9	102.3	89.9	75.7	>100