Figure 3: Proportion of responders among all eligible patients using the intention-to-treat principle, according to treatment group assignment. Compared with GJS-P plus DUO-P group, GSJ plus DUO group, GJS-P plus DUO group, and GJS plus DUO-P group showed statistically significant improvement during 8 weeks of administration period. Proportion of responders: proportion of patients who showed adequate relief of overall irritable bowel syndrome symptoms on at least half of the total weekly assessments (range: 0-1). GJS: Gwakhyangjeonggisan, DUO: Duolac7S, GJS-P: placebo of Gwakhyangjeonggisan, DUO-P: placebo of Duolac7S, * , ** .