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Evidence-Based Complementary and Alternative Medicine
Volume 2013, Article ID 824960, 8 pages
http://dx.doi.org/10.1155/2013/824960
Research Article

QSYQ Attenuates Oxidative Stress and Apoptosis Induced Heart Remodeling Rats through Different Subtypes of NADPH-Oxidase

1Beijing University of Chinese Medicine, Bei San Huan Dong Lu 11, Chao Yang District, 100029 Beijing, China
2Capital Medical University Beijing Anzhen Hospital, Beijing, China

Received 4 March 2013; Revised 8 May 2013; Accepted 11 May 2013

Academic Editor: Keji Chen

Copyright © 2013 Yong Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. Lloyd-Jones, R. J. Adams, T. M. Brown et al., “Heart disease and stroke statistics-2010 update: a report from the American Heart Association,” Circulation, vol. 121, pp. e46–e215, 2010. View at Publisher · View at Google Scholar
  2. A. V. Ambardekar and P. M. Buttrick, “Reverse remodeling with left ventricular assist devices a review of clinical, cellular, and molecular effects,” Circulation: Heart Failure, vol. 4, no. 2, pp. 224–233, 2011. View at Publisher · View at Google Scholar · View at Scopus
  3. Y. Wang, W. J. Chuo, C. Li et al., “Energy metabolism disorder and myocardial injury in chronic myocardial ischemia with Qi deficiency and blood stasis syndrome based on 2-DE proteomics,” Chinese Journal of Integrative Medicine, 2012. View at Publisher · View at Google Scholar
  4. A. Blum, “Heart failure–new insights,” The Israel Medical Association Journal, vol. 11, no. 2, pp. 105–111, 2009. View at Google Scholar
  5. A. Rashikh, S. J. Ahmad, K. K. Pillai, K. Kohli, and A. K. Najmi, “Aliskiren attenuates myocardial apoptosis and oxidative stress in chronic murine model of cardiomyopathy,” Biomedicine and Pharmacotherapy, vol. 66, no. 2, pp. 138–143, 2012. View at Publisher · View at Google Scholar · View at Scopus
  6. H. Tsutsui, S. Kinugawa, and S. Matsushima, “Oxidative stress and heart failure,” American Journal of Physiology, vol. 301, no. 6, pp. 2181–2190, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. M. Zhang, A. Perino, A. Ghigo, E. Hirsch, and A. M. Shah, “NADPH oxidases in heart failure: poachers or gamekeepers?” Antioxidants & Redox Signaling, vol. 18, no. 9, pp. 1024–1041, 2013. View at Publisher · View at Google Scholar
  8. K. Schröder, M. Zhang, S. Benkhoff et al., “Nox4 is a protective reactive oxygen species generating vascular NADPH oxidase,” Circulation Research, vol. 110, no. 9, pp. 1217–1225, 2012. View at Publisher · View at Google Scholar · View at Scopus
  9. A. V. Maksimenko and A. V. Vavaev, “Antioxidant enzymes as potential targets in cardioprotection and treatment of cardiovascular diseases. Enzyme antioxidants: the next stage of pharmacological counterwork to the oxidative stress,” Heart International, vol. 7, no. 1, pp. 14–19, 2012. View at Publisher · View at Google Scholar · View at Scopus
  10. Y. Hojo, T. Saito, and H. Kondo, “Role of apoptosis in left ventricular remodeling after acute myocardial infarction,” Journal of Cardiology, vol. 60, no. 2, pp. 91–92, 2012. View at Google Scholar
  11. K. Hayakawa, G. Takemura, M. Kanoh et al., “Inhibition of granulation tissue cell apoptosis during the subacute stage of myocardial infarction improves cardiac remodeling and dysfunction at the chronic stage,” Circulation, vol. 108, no. 1, pp. 104–109, 2003. View at Publisher · View at Google Scholar · View at Scopus
  12. X. Feng, X. Liu, W. Zhang, and W. Xiao, “p53 directly suppresses BNIP3 expression to protect against hypoxia-induced cell death,” The EMBO Journal, vol. 30, no. 16, pp. 3397–3415, 2011. View at Publisher · View at Google Scholar · View at Scopus
  13. A. Abbate, R. Bussani, M. S. Amin, G. W. Vetrovec, and A. Baldi, “Acute myocardial infarction and heart failure: role of apoptosis,” International Journal of Biochemistry and Cell Biology, vol. 38, no. 11, pp. 1834–1840, 2006. View at Publisher · View at Google Scholar · View at Scopus
  14. G. Dai, B. Zhang, and Z. Guo, “Application of central randomized system in project of clinical trial for secondary prevention of myocardial infarction by Qishen Yiqi Drop Pill,” Zhongguo Zhong Xi Yi Jie He Za Zhi, vol. 27, no. 7, pp. 653–656, 2007. View at Google Scholar · View at Scopus
  15. Y. Wang, Z. Liu, C. Li et al., “Drug target prediction based on the herbs components: the study on the multitargets pharmacological mechanism of Qishenkeli acting on the coronary heart disease,” Evidence-Based Complementary and Alternative Medicine, vol. 2012, Article ID 698531, 10 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
  16. Y. Wang, C. Li, Y. Ouyang et al., “Cardioprotective effects of Qishenyiqi mediated by angiotensin II type 1 receptor blockade and enhancing angiotensin-converting enzyme 2,” Evidence-Based Complementary and Alternative Medicine, vol. 2012, Article ID 978127, 9 pages, 2012. View at Publisher · View at Google Scholar
  17. X. J. Song, C. Y. Yang, B. Liu et al., “Atorvastatin inhibits myocardial cell apoptosis in a rat model with post-myocardial infarction heart failure by downregulating ER stress response,” International Journal of Medical Sciences, vol. 8, no. 7, pp. 564–572, 2011. View at Google Scholar · View at Scopus
  18. A. Shirakabe, K. Asai, N. Hata et al., “Immediate administration of atorvastatin decreased the serum MMP-2 level and improved the prognosis for acute heart failure,” Journal of Cardiology, vol. 59, no. 3, pp. 374–382, 2012. View at Publisher · View at Google Scholar · View at Scopus
  19. J. R. Burgoyne, H. Mongue-Din, P. Eaton, and A. M. Shah, “Redox signaling in cardiac physiology and pathology,” Circulation Research, vol. 111, no. 8, pp. 1091–1106, 2012. View at Publisher · View at Google Scholar
  20. Y. Jiang, Y. Miao, L. Yang et al., “Effect of chinese herbal drug-containing serum for activating-blood and dispelling-toxin on ox-LDL-induced inflammatory factors' expression in endothelial cells,” Chinese Journal of Integrative Medicine, vol. 18, no. 1, pp. 30–33, 2012. View at Publisher · View at Google Scholar · View at Scopus
  21. J. Kuroda and J. Sadoshima, “NADPH oxidase and cardiac failure,” Journal of Cardiovascular Translational Research, vol. 3, no. 4, pp. 314–320, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. M. Bao, W. Dai, Y. Li, and C. Hu, “Rutaecarpine prevents hypoxia-reoxygenation-induced myocardial cell apoptosis via inhibition of NADPH oxidases,” Canadian Journal of Physiology and Pharmacology, vol. 89, no. 3, pp. 177–186, 2011. View at Publisher · View at Google Scholar · View at Scopus
  23. A. Nabeebaccus, M. Zhang, and A. M. Shah, “NADPH oxidases and cardiac remodelling,” Heart Failure Reviews, vol. 16, no. 1, pp. 5–12, 2011. View at Publisher · View at Google Scholar · View at Scopus
  24. R. Cangemi, A. Celestini, M. Del Ben et al., “Role of platelets in NOX2 activation mediated by TNFα in heart failure,” Internal and Emergency Medicine, vol. 28, 2012. View at Publisher · View at Google Scholar
  25. K. T. Moe, N. O. Yin, T. M. Naylynn et al., “Nox2 and Nox4 mediate tumour necrosis factor-α-induced ventricular remodelling in mice,” Journal of Cellular and Molecular Medicine, vol. 15, no. 12, pp. 2601–2613, 2011. View at Publisher · View at Google Scholar · View at Scopus
  26. R. Dworakowski, S. P. Alom-Ruiz, and A. M. Shah, “NADPH oxidase-derived reactive oxygen species in the regulation of endothelial phenotype,” Pharmacological Reports, vol. 60, no. 1, pp. 21–28, 2008. View at Google Scholar · View at Scopus
  27. A. van der Vliet, “NADPH oxidases in lung biology and pathology: host defense enzymes, and more,” Free Radical Biology and Medicine, vol. 44, no. 6, pp. 938–955, 2008. View at Publisher · View at Google Scholar · View at Scopus
  28. R. P. Brandes, N. Weissmann, and K. Schröder, “NADPH oxidases in cardiovascular disease,” Free Radical Biology and Medicine, vol. 49, no. 5, pp. 687–706, 2010. View at Publisher · View at Google Scholar · View at Scopus
  29. Y. Maejima, J. Kuroda, S. Matsushima, T. Ago, and J. Sadoshima, “Regulation of myocardial growth and death by NADPH oxidase,” Journal of Molecular and Cellular Cardiology, vol. 50, no. 3, pp. 408–416, 2011. View at Publisher · View at Google Scholar · View at Scopus
  30. T. Chen, X. Z. Zhou, R. S. Zhang, and L. W. Zhang, “Discovery of regularities in the use of herbs in chinese medicine prescriptions,” Chinese Journal of Integrative Medicine, vol. 18, no. 2, pp. 88–92, 2012. View at Publisher · View at Google Scholar
  31. A. S. Ferreira and A. J. Lopes, “Chinese medicine pattern differentiation and its implications for clinical practice,” Chinese Journal of Integrative Medicine, vol. 17, no. 11, pp. 818–823, 2011. View at Google Scholar · View at Scopus