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Evidence-Based Complementary and Alternative Medicine
Volume 2013, Article ID 834027, 11 pages
http://dx.doi.org/10.1155/2013/834027
Research Article

Oral Administration of Alkylglycerols Differentially Modulates High-Fat Diet-Induced Obesity and Insulin Resistance in Mice

1Xinhua Hospital, Shanghai Institute for Pediatric Research, Shanghai Jiao Tong University, School of Medicine, Shanghai 200092, China
2Department of Immunology, Nanjing Medical University, Nanjing 210029, China
3Fudan Children’s Hospital, Fudan University, School of Medicine, Shanghai 201102, China
4Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Shanghai 200092, China

Received 1 January 2013; Accepted 5 June 2013

Academic Editor: Wei Jia

Copyright © 2013 Mingshun Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Alkylglycerols (AKGs) from shark liver oil (SLO) were demonstrated to have strong potency to stimulate immune response. However, no study has been conducted on the effects of AKGs on diet-induced obesity and metabolic inflammatory disorder. The purpose of the present study was to investigate the effect of two AKGs isoforms on obesity and insulin resistance in mice fed high-fat (HF) diet. Forty-eight C57BL/6 mice were divided into normal, HF,  mg/kg selachyl alcohol (SA),  mg/kg SA,  mg/kg batyl alcohol (BA), and  mg/kg BA groups. Body weight, fasting glucose, lipids, insulin and leptin levels, serum IL-1β, and TNF-α levels were compared among different groups. Our results showed that high-dose SA decreased body weight, serum triglyceride, cholesterol, fasting glucose level, insulin level, and serum leptin level of the HF fed mice, while high-dose BA increased fasting insulin level of the HF fed mice. Pretreatment of primary adipocytes with 10 μM SA or BA differentially modulates LPS-mediated MAPK and NF-κB signaling. Our study demonstrated that oral administration of AKGs has differential effects on HF-induced obesity and metabolic inflammatory disorder in mice.