Oral Administration of Alkylglycerols Differentially Modulates High-Fat Diet-Induced Obesity and Insulin Resistance in Mice

Table 2

The effect of selachyl alcohol (SA) or batyl alcohol (BA) supplementation on serum glucose, insulin, and Homeostatic Model Assessment-Insulin Resistance (HOMA-IR) before and after 100 ng lipopolysaccharide (LPS) challenge.

		Pre-LPS^1
							P value^4	P value	P value
Item	ND^2	HF	HF + 20 mg/kg SA	HF + 200 mg/kg SA	HF + 20 mg/kg BA	HF + 200 mg/kg BA	(HF)	(SA)	(BA)
Glucose (mmol/L)	7.62±0.30^3	9.84±0.34	8.69±0.20^∗	7.47±0.29^∗	10.03±0.37	10.06±0.54	<0.001	<0.001	0.761
Insulin (μIU/mL)	13.49±1.14	27.81±1.85	25.05±2.03	20.92±1.5^∗	25.33±2.73	34.41±2.03^†	<0.001	0.043	0.025
HOMA-IR	4.63±0.54	12.11±0.78	9.71±0.86^∗	7.00±0.69^∗	11.12±1.02	15.39±1.17^†	<0.001	<0.001	0.017
		Post-LPS
Glucose (mmol/L)	6.19±0.30	5.71±0.16	5.73±0.21	5.05±0.22^∗	5.16±0.15	5.88±0.30	0.182	0.038	0.062
Insulin (μIU/mL)	21.20±3.35	37.13±2.86	33.03±3.65	22.99±3.08^∗	33.86±2.42	39.92±2.33	<0.005	0.018	0.246
HOMA-IR	5.71±0.79	9.48±0.91	8.35±0.91	5.11±0.70^∗	7.80±0.62	10.62±1.08	0.008	0.004	0.096

1Serum glucose and insulin were measured before LPS challenge (Pre-LPS) and 2 hours following 100 ng LPS challenge (Post-LPS). 2ND: normal diet; HF: high-fat diet; SA: selachyl alcohol; BA: batyl alcohol. 3Values are mean ± SEM. Means with a mark (*) in HF + 20 mg/kg SA or HF + 200 mg/kg SA group differ significantly from the HF diet group. Means with a mark (^†) in HF + 20 mg/kg BA or HF + 200 mg/kg BA group differ significantly from the HF diet group. 4P value (HF) indicates the effect of HF treatment. P value (SA) indicates the effect of different doses of SA supplements on HF fed mice. P value (BA) indicates the effect of different doses of BA supplements on HF fed mice.