Gastrointestinal and Hepatotoxicity Assessment of an Anticancer Extract from Muricid Molluscs
Figure 4
Transverse liver sections showing (a) focal necrosis (arrow head), (b) submassive necrosis (arrow head), and (c) macro- and microvesicular change (arrow head) in mice administered 0.125 mg/g muricid extract stained in haematoxylin and eosin, (d) unstained macrovesicular inclusions (arrow heads) and (e) microvesicular fatty inclusions stained with Oil Red O (arrow heads) in mice administered 0.125 mg/g muricid extract, and (f) normal hepatocytes in a control mouse stained with haematoxylin and eosin. Abbreviations: A, artery; BD, bile duct; CV, central vein (centrilobular, zone 3); N, nucleus; PV, portal vein (periportal, zone 1). Scale bars = 100 μm (a-b) and 10 μm (c)–(f).
