Gastrointestinal and Hepatotoxicity Assessment of an Anticancer Extract from Muricid Molluscs

Table 1

Mean (±S.D.) organ weight as a percent of total body weight in control mice (0.0 mg/g, 𝑁 = 4) and mice administered 0.125 mg/g (𝑁 = 8), 0.5 mg/g (𝑁 = 7) and 1.0 mg/g (𝑁 = 6) of muricid extract (ME). Significant differences (𝑃<0.05) between control and ME-treated mice are indicated by *.

ME dose (mg/g)	Percent of body weight (%)
	Colon	Small intestine	Liver	Kidney	Spleen
0.000	0.68±0.22	3.47±1.33	5.11±0.66	1.43±0.08	0.36±0.03
0.125	0.78±0.07	4.17±0.29	4.29±0.16^∗	1.40±0.08	0.41±0.04
0.500	0.71±0.13	4.53±0.74	4.76±0.33	1.43±0.09	0.39±0.05
1.000	0.92±0.09^∗	4.65±0.19^∗	5.26±0.26	1.65±0.04^∗	0.42±0.04