Hinokitiol, a Natural Tropolone Derivative, Offers Neuroprotection from Thromboembolic Stroke In Vivo
(a) Effects of hinokitiol in ischemia/reperfusion brain injury induced by MCAO in rats. Digital photographs show the infarct region in brain sections stained by 2% TTC 24 h after MCAO. (b) Dose-response effect of hinokitiol in ischemia/reperfusion brain injury induced by MCAO in rats. Rats were injected with solvent or hinokitiol (0.2 or 0.5 mg/kg, i.p.) at the time of 30 min before the onset of MCAO compared to sham control. Data are presented as percentage of contralateral hemisphere and expressed as means ± SEM. compared with sham group; compared with vehicle control group (n = 10~15).