Herbal Medicine Goshajinkigan Prevents Paclitaxel-Induced Mechanical Allodynia without Impairing Antitumor Activity of Paclitaxel
Figure 4
Paclitaxel- (PTX-) induced mechanical allodynia with or without Goshajinkigan (GJG) administration in mice with breast cancer. PTX (10 and 20 mg/kg) and vehicle (VH1) were injected intraperitoneally, and GJG (1 g/kg) and vehicle (VH2) were administered orally, as described in Figure 1 legend. The evaluation of pain-related responses using a von Frey filament was performed before drug administration every day. (a) The site of allodynia evaluation. ((b), (c)) Time-course of allodynia induced by PTX administration (b) with or (c) without GJG administration. Values represent the means ± SEM. Figures in parentheses indicate the number of animals. (b) Main effect of PTX treatment, , ; interaction between PTX treatment and time, , (two-way repeated measures ANOVA).
