A Study on the Mechanism of Cinobufagin in the Treatment of Paw Cancer Pain by Modulating Local β-Endorphin Expression In Vivo
Figure 1
The representative morphological photographs of the mouse right and left paws and representative photomicrographs of mice right paws with hematoxylin and eosin on different days after injection of the cancer cell line H22. Upper images: representative morphological photographs of the mouse right and left paws; lower images: representative photomicrographs of mice right paws with hematoxylin and eosin, which were found to have a large number of cancer cells (labeled with blue arrowheads) on the 4th day after inoculation. There was a tendency for bone invasion which began on the 10th day, and bone tissue was destroyed in the first 20 days and was further damaged on the 30th day. (a) 0 day; (b) 4 days; (c) 6 days; (d) 8 days; (e) 10 days; (f) 20 days; (g) 30 days.
