A Study on the Mechanism of Cinobufagin in the Treatment of Paw Cancer Pain by Modulating Local β-Endorphin Expression In Vivo
Figure 3
Effect of cinobufagin on mechanical hyperalgesia at different times. Cinobufagin significantly increased the pain threshold on the 4th day, which increased gradually up to the 8th day, which was blocked by the peripheral opioid receptor antagonist NAL-M. Data are shown as the mean ± SD (). #, ## compared to model group.
