A Study on the Mechanism of Cinobufagin in the Treatment of Paw Cancer Pain by Modulating Local β-Endorphin Expression In Vivo

Figure 5

The representative photomicrographs of the tumor and adjacent tissues POMC immunohistochemistry (400x) and effect of Cinobufagin on the tumor and adjacent tissue POMC protein expressions in the cancer pain mice. (a) Control group; (b) model group; (c) cinobufagin group (cinobufagin, 10 mL/kg/day, i.p.); (d) cinobufagin + NAL-M group (cinobufagin, 10 mL/kg/day, NAL-M, 20 mg/kg/day i.p.); (e) morphine group (morphine, 8 mg/kg/day, i.p.). (f) Effect of cinobufagin on the tumor and adjacent tissue POMC protein expression. Label with red arrowheads represents POMC positive expression. Data are shown as the mean ± SD (𝑛=6). ^#𝑃<0.05, ^##𝑃<0.01 compared to control group; *𝑃<0.05, **𝑃<0.01 compared to model group.

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