Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2013 (2013), Article ID 851267, 11 pages
http://dx.doi.org/10.1155/2013/851267
Research Article

Antihyperglycemic Effects of Short Term Resveratrol Supplementation in Type 2 Diabetic Patients

1Department of Endocrine and Metabolic Diseases, The Persian Gulf Tropical Medicine Research Center, Bushehr, University of Medical Sciences, Bushehr 7514763448, Iran
2Heart Failure Research Laboratory, Canadian Centre for Agri-Food Research in Health and Medicine, St. Boniface Research Centre, Winnipeg, MB, Canada R2H 2A6
3Agriculture and Agri-Food Canada, Winnipeg, MB, Canada R3T 2M9
4Department of Physiology, University of Manitoba, Winnipeg, MB, Canada R3E 0J9

Received 13 June 2013; Accepted 25 July 2013

Academic Editor: MinKyun Na

Copyright © 2013 Ali Movahed et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [57 citations]

The following is the list of published articles that have cited the current article.

  • Vernon W. Dolinsky, and Jason R. B. Dyck, “Experimental Studies of the Molecular Pathways Regulated by Exercise and Resveratrol in Heart, Skeletal Muscle and the Vasculature,” Molecules, vol. 19, no. 9, pp. 14919–14947, 2014. View at Publisher · View at Google Scholar
  • Kai Liu, Rui Zhou, Bin Wang, and Man-Tian Mi, “Effect of resveratrol on glucose control and insulin sensitivity: a meta-analysis:of 11 randomized controlled trials,” American Journal of Clinical Nutrition, vol. 99, no. 6, pp. 1510–1519, 2014. View at Publisher · View at Google Scholar
  • Stephen D. Anton, Chelsea Embry, Michael Marsiske, Xiaomin Lu, Hani Doss, Christiaan Leeuwenburgh, and Todd M. Manini, “Safety and metabolic outcomes of resveratrol supplementation in older adults: results of a twelve-week, placebo-controlled pilot study,” Experimental Gerontology, 2014. View at Publisher · View at Google Scholar
  • Yanxia Liu, Wanqiang Ma, Po Zhang, Shunchuan He, and Daifa Huang, “Effect of resveratrol on blood pressure: A meta-analysis of randomized controlled trials,” Clinical Nutrition, 2014. View at Publisher · View at Google Scholar
  • Thais Fernandes Luciano, Scherolin de Oliveira Marques, Bruno Luiz da Silva Pieri, Daniela Roxo de Souza, Fabio Santos de Lira, and Claudio Teodoro de Souza, “Resveratrol reduces chronic inflammation and improves insulin action in the myocardium of high-fat diet-induced obese rats,” Revista de Nutricao-Brazilian Journal of Nutrition, vol. 27, no. 2, pp. 151–159, 2014. View at Publisher · View at Google Scholar
  • Veronique S. Chachay, Graeme A. Macdonald, Jennifer H. Martin, Jonathan P. Whitehead, Trisha M. O'Moore–Sullivan, Paul Lee, Michael Franklin, Kerenaftali Klein, Paul J. Taylor, Maree Ferguson, Jeff S. Coombes, Gethin P. Thomas, Gary J. Cowin, Carl M.J. Kirkpatrick, Johannes B. Prins, and Ingrid J. Hickman, “Resveratrol Does Not Benefit Patients With Nonalcoholic Fatty Liver Disease,” Clinical Gastroenterology and Hepatology, 2014. View at Publisher · View at Google Scholar
  • Beshay N.M. Zordoky, Ian M. Robertson, and Jason R.B. Dyck, “Preclinical and Clinical Evidence for the Role of Resveratrol in the Treatment of Cardiovascular Diseases,” Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2014. View at Publisher · View at Google Scholar
  • Marlies de Ligt, Silvie Timmers, and Patrick Schrauwen, “Resveratrol and obesity: can resveratrol relieve metabolic disturbances?,” Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2014. View at Publisher · View at Google Scholar
  • Michael Rouse, Antoine Younes, and Josephine M. Egan, “Resveratrol and curcumin enhance pancreatic beta-cell function by inhibiting phosphodiesterase activity,” Journal of Endocrinology, vol. 223, no. 2, pp. 107–117, 2014. View at Publisher · View at Google Scholar
  • Agustin Gonzalez-Vicente, Pablo D. Cabral, and Jeffrey L. Garvin, “Resveratrol Increases Nitric Oxide Production in the Rat Thick Ascending Limb via Ca2+/Calmodulin,” Plos One, vol. 9, no. 10, 2014. View at Publisher · View at Google Scholar
  • Heather A. Hausenblas, Jennifer A. Schoulda, and James M. Smoliga, “Resveratrol treatment as an adjunct to pharmacological management in type 2 diabetes mellitus-systematic review and meta-analysis,” Molecular Nutrition & Food Research, 2014. View at Publisher · View at Google Scholar
  • Tomasz Szkudelski, and Katarzyna Szkudelska, “Resveratrol and diabetes: from animal to human studies,” Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2014. View at Publisher · View at Google Scholar
  • Bhakkiyalakshmi Elango, Sireesh Dornadula, Rajaguru Palanisamy, Paulmurugan Ramasamy, and Ramkumar Kunka Mohanram, “The emerging role of redox-sensitive Nrf2-Keap1 pathway in diabetes,” Pharmacological Research, 2014. View at Publisher · View at Google Scholar
  • H-H Chow, Linda L Garland, Brandy M Heckman-Stoddard, Chiu-Hsieh Hsu, Valerie D Butler, Catherine A Cordova, Wade M Chew, and Terri L Cornelison, “A pilot clinical study of resveratrol in postmenopausal women with high body mass index: effects on systemic sex steroid hormones,” Journal of Translational Medicine, vol. 12, no. 1, pp. 223, 2014. View at Publisher · View at Google Scholar
  • Xuan Yang, Jinyu Ren, and Xun Li, “From French Paradox to cancer treatment: Anti-cancer activities and mechanisms of resveratrol,” Anti-Cancer Agents in Medicinal Chemistry, vol. 14, no. 6, pp. 806–825, 2014. View at Publisher · View at Google Scholar
  • Mahmoud Hussein Hassan Ali, Basim Anwar Shehata Messiha, and Hekma Abdel-Tawab Abdel-Latif, “ Protective effect of ursodeoxycholic acid, resveratrol, and N -acetylcysteine on nonalcoholic fatty liver disease in rats ,” Pharmaceutical Biology, pp. 1–11, 2015. View at Publisher · View at Google Scholar
  • Qiuhua Shen, and Janet Pierce, “Supplementation of Coenzyme Q10 among Patients with Type 2 Diabetes Mellitus,” Healthcare, vol. 3, no. 2, pp. 296–309, 2015. View at Publisher · View at Google Scholar
  • Nimbe Torres, Martha Guevara-Cruz, Laura A. Velázquez-Villegas, and Armando R. Tovar, “,” Archives of Medical Research, 2015. View at Publisher · View at Google Scholar
  • Yonglin Gao, Le Kang, Chunmei Li, Xiaoyan Wang, Chengfeng Sun, Qingzhong Li, Ruihua Liu, and Jianping Wang, “Resveratrol Ameliorates Diabetes-Induced Cardiac Dysfunction Through AT1R-ERK/p38 MAPK Signaling Pathway,” Cardiovascular Toxicology, 2015. View at Publisher · View at Google Scholar
  • Susana A. Palma-Duran, Antonis Vlassopoulos, Mike Lean, Lindsay Govan, and Emilie Combet, “Nutritional Intervention and Impact of Polyphenol on Glycohaemoglobin (HbA1c) in Non-diabetic and Type 2 Diabetic Subjects: Systematic Review and Meta-analysis,” Critical Reviews in Food Science and Nutrition, pp. 00–00, 2015. View at Publisher · View at Google Scholar
  • Brian J. Morris, Randi Chen, Timothy A. Donlon, Daniel S. Evans, Gregory J. Tranah, Neeta Parimi, Georg B. Ehret, Christopher Newton-Cheh, Todd Seto, D. Craig Willcox, Kamal H. Masaki, Kei Kamide, Hirochika Ryuno, Ryosuke Oguro, Chikako Nakama, Mai Kabayama, Koichi Yamamoto, Ken Sugimoto, Kazunori Ikebe, Yukie Masui, Yasumichi Arai, Tatsuro Ishizaki, Yasuyuki Gondo, Hiromi Rakugi, and Bradley J. Willcox, “ Association Analysis of FOXO3 Longevity Variants With Blood Pressure and Essential Hypertension ,” American Journal of Hypertension, pp. hpv171, 2015. View at Publisher · View at Google Scholar
  • Marta G. Novelle, Devin Wahl, Carlos Dieguez, Michel Bernier, and Rafael de Cabo, “Resveratrol supplementation, where are we now and where should we go?,” Ageing Research Reviews, 2015. View at Publisher · View at Google Scholar
  • Eun-Jung Park, and John M. Pezzuto, “The Pharmacology of Resveratrol in Animals and Humans,” Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2015. View at Publisher · View at Google Scholar
  • An-Sheng Cheng, Yu-Hsiang Cheng, Chi-Ying Lee, Chin-Yuan Chung, and Wen-Chang Chang, “Resveratrol Protects against Methylglyoxal-Induced Hyperglycemia and Pancreatic Damage In Vivo,” Nutrients, vol. 7, no. 4, pp. 2850–2865, 2015. View at Publisher · View at Google Scholar
  • S. Bo, V. Ponzo, G. Ciccone, A. Evangelista, F. Saba, I. Goitre, M. Procopio, G.F. Pagano, M. Cassader, and R. Gambino, “Six months of resveratrol supplementation has no measurable effect in type 2 diabetic patients. A randomized, double blind, placebo-controlled trial,” Pharmacological Research, vol. 111, pp. 896–905, 2016. View at Publisher · View at Google Scholar
  • Prachi Gupta, Manju Bala, Sanjeev Gupta, Anita Dua, Rajesh Dabur, Elisha Injeti, and Ashwani Mittal, “Efficacy and Risk profile of Anti-diabetic therapies: Conventional vs traditional drugs-A mechanistic revisit to understand their mode of action,” Pharmacological Research, 2016. View at Publisher · View at Google Scholar
  • Haohai Huang, Guangzhao Chen, Dan Liao, Yongkun Zhu, Rong Pu, and Xiaoyan Xue, “The effects of resveratrol intervention on risk markers of cardiovascular health in overweight and obese subjects: a pooled analysis of randomized controlled trials,” Obesity Reviews, 2016. View at Publisher · View at Google Scholar
  • Julia Christenson, Serena J. Whitby, Duane Mellor, Jackson Thomas, Andrew McKune, Paul D. Roach, and Nenad Naumovski, “The Effects of Resveratrol Supplementation in Overweight and Obese Humans: A Systematic Review of Randomized Trials,” Metabolic Syndrome and Related Disorders, 2016. View at Publisher · View at Google Scholar
  • Ali Movahed, Afshin Ostovar, Pema Raj, Thomas Netticadan, Daryoush Iranpour, Sijo Joseph Thandapilly, Xavier Lieben Louis, and James Michael Smoliga, “The efficacy of resveratrol in controlling hypertension: Study protocol for a randomized, crossover, double-blinded, placebo-controlled trial,” Trials, vol. 17, no. 1, 2016. View at Publisher · View at Google Scholar
  • Cihan Erdogan, and Ole Vang, “Challenges in Analyzing the Biological Effects of Resveratrol,” Nutrients, vol. 8, no. 6, pp. 353, 2016. View at Publisher · View at Google Scholar
  • Hnin Ei Phyu, Jordon Candice Irwin, Rebecca Kate Vella, and Andrew Stuart Fenning, “Resveratrol shows neuronal and vascular-protective effects in older, obese, streptozotocin-induced diabetic rats,” British Journal Of Nutrition, vol. 115, no. 11, pp. 1911–1918, 2016. View at Publisher · View at Google Scholar
  • Ning Xia, Andreas Daiber, Ulrich Förstermann, and Huige Li, “Antioxidant effects of resveratrol in the cardiovascular system,” British Journal of Pharmacology, vol. 174, no. 12, pp. 1633–1646, 2016. View at Publisher · View at Google Scholar
  • Khushwant S. Bhullar, and Chibuike C. Udenigwe, “Clinical Evidence of Resveratrol Bioactivity in Cardiovascular Disease,” Current Opinion in Food Science, 2016. View at Publisher · View at Google Scholar
  • Soon-Sen Leow, Julia Bolsinger, Andrzej Pronczuk, K. C. Hayes, and Ravigadevi Sambanthamurthi, “Hepatic transcriptome implications for palm fruit juice deterrence of type 2 diabetes mellitus in young male Nile rats,” Genes & Nutrition, vol. 11, no. 1, 2016. View at Publisher · View at Google Scholar
  • Sony S. Thazhath, Tongzhi Wu, Michelle J. Bound, Helen L. Checklin, Scott Standfield, Karen L. Jones, Michael Horowitz, and Christopher K. Rayner, “Administration of resveratrol for 5 wk has no effect on glucagon-like peptide 1 secretion, gastric emptying, or glycemic control in type 2 diabetes: a,” American Journal Of Clinical Nutrition, vol. 103, no. 1, pp. 66–70, 2016. View at Publisher · View at Google Scholar
  • Razie Hormoznejad, Parvin Dehghan, Maryam Ravanbakhsh, Ahmad Zare Javid, Hojat allah Yousefimanesh, Mehrnoosh Zakerkish, and Mohammad Hosein Haghighi-zadeh, “The Impact of Resveratrol Supplementation on Blood Glucose, Insulin, Insulin Resistance, Triglyceride, and Periodontal Markers in Type 2 Diabetic Patients with Chronic Periodontitis,” Phytotherapy Research, vol. 31, no. 1, pp. 108–114, 2016. View at Publisher · View at Google Scholar
  • José Pedraza-Chaverri, Laura G. Sánchez-Lozada, Horacio Osorio-Alonso, Edilia Tapia, and Alexandra Scholze, “New Pathogenic Concepts and Therapeutic Approaches to Oxidative Stress in Chronic Kidney Disease,” Oxidative Medicine and Cellular Longevity, vol. 2016, pp. 1–21, 2016. View at Publisher · View at Google Scholar
  • Omolola R. Oyenihi, Ayodeji B. Oyenihi, Anne A. Adeyanju, and Oluwafemi O. Oguntibeju, “Antidiabetic Effects of Resveratrol: The Way Forward in Its Clinical Utility,” Journal of Diabetes Research, vol. 2016, pp. 1–14, 2016. View at Publisher · View at Google Scholar
  • Vera B. Schrauwen-Hinderling, Patrick Schrauwen, Esther Phielix, Esther Moonen-Kornips, Gert Schaart, Iris Kunz, Matthijs K. C. Hesselink, Silvie Timmers, Marlies De Ligt, Tineke Van De Weijer, and Jan Hansen, “Resveratrol as add-on therapy in subjects with well-controlled type 2 diabetes: A randomized controlled trial,” Diabetes Care, vol. 39, no. 12, pp. 2211–2217, 2016. View at Publisher · View at Google Scholar
  • Xiangyun Zhu, Chunhua Wu, Shanhu Qiu, Xuelu Yuan, and Ling Li, “Effects of resveratrol on glucose control and insulin sensitivity in subjects with type 2 diabetes: systematic review and meta-analysis,” Nutrition & Metabolism, vol. 14, no. 1, 2017. View at Publisher · View at Google Scholar
  • Xiao-Fei Guo, Jiao-Mei Li, Jun Tang, and Duo Li, “Effects of resveratrol supplementation on risk factors of non-communicable diseases: A meta-analysis of randomized controlled trials,” Critical Reviews in Food Science and Nutrition, pp. 1–15, 2017. View at Publisher · View at Google Scholar
  • Awais Wahab, Kuo Gao, Caixia Jia, Feilong Zhang, Guihua Tian, Ghulam Murtaza, and Jianxin Chen, “Significance of Resveratrol in Clinical Management of Chronic Diseases,” Molecules, vol. 22, no. 8, pp. 1329, 2017. View at Publisher · View at Google Scholar
  • Ebrahim Abbasi Oshaghi, Mohammad Taghi Goodarzi, Victoria Higgins, and Khosrow Adeli, “Role of resveratrol in the management of insulin resistance and related conditions: Mechanism of action,” Critical Reviews in Clinical Laboratory Sciences, pp. 1–27, 2017. View at Publisher · View at Google Scholar
  • Y. Lian, C. Gao, Y. Wu, J. Xia, Y. Leng, Y. Liu, M. Zhu, J. Chen, and Z. Qi, “Suppression of Delayed Xenograft Rejection by Resveratrol in a Hamster-to-Rat Cardiac Transplantation Model,” Transplantation Proceedings, vol. 49, no. 6, pp. 1483–1491, 2017. View at Publisher · View at Google Scholar
  • Sanghyun Cho, Kyung Namkoong, Minji Shin, Jueun Park, Eunyeong Yang, Jinsoo Ihm, Vu Thi Thu, Hyoung Kyu Kim, and Jin Han, “Cardiovascular Protective Effects and Clinical Applications of Resveratrol,” Journal of Medicinal Food, vol. 20, no. 4, pp. 323–334, 2017. View at Publisher · View at Google Scholar
  • Ana Marta de Matos, Maria Paula de Macedo, and Amélia Pilar Rauter, “Bridging Type 2 Diabetes and Alzheimer's Disease: Assembling the Puzzle Pieces in the Quest for the Molecules With Therapeutic and Preventive Potential,” Medicinal Research Reviews, 2017. View at Publisher · View at Google Scholar
  • Shintaro Yamaguchi, and Jun Yoshino, “ Adipose tissue NAD + biology in obesity and insulin resistance: From mechanism to therapy ,” BioEssays, pp. 1600227, 2017. View at Publisher · View at Google Scholar
  • Anil Kumar, and Ruchika Mittal, “Nrf2: a potential therapeutic target for diabetic neuropathy,” Inflammopharmacology, 2017. View at Publisher · View at Google Scholar
  • Ha T. Tran, Stella Liong, Ratana Lim, Gillian Barker, and Martha Lappas, “Resveratrol ameliorates the chemical and microbial induction of inflammation and insulin resistance in human placenta, adipose tissue and skeletal muscle,” Plos One, vol. 12, no. 3, pp. e0173373, 2017. View at Publisher · View at Google Scholar
  • David León, Elena Uribe, Angara Zambrano, and Mónica Salas, “Implications of Resveratrol on Glucose Uptake and Metabolism,” Molecules, vol. 22, no. 3, pp. 398, 2017. View at Publisher · View at Google Scholar
  • Tomasz Charytoniuk, Krzysztof Drygalski, Karolina Konstantynowicz-Nowicka, Klaudia Berk, and Adrian Chabowski, “Alternative treatment methods attenuate the development of NAFLD: A review of resveratrol molecular mechanisms and clinical trials,” Nutrition, vol. 34, pp. 108–117, 2017. View at Publisher · View at Google Scholar
  • William M. Schultz, Elliot N. Mahlof, Devinder S. Dhindsa, Tina Varghese, Robert E. Heinl, Hannah C. Cai, Pratik B. Sandesara, Danny J. Eapen, and Laurence S. Sperling, “Cardiovascular disease risk reduction in diabetes through conventional and natural approaches,” Cardiovascular Endocrinology, vol. 6, no. 4, pp. 128–135, 2017. View at Publisher · View at Google Scholar
  • Ebru Öztürk, Ayşe Kübra Karaboğa Arslan, Mükerrem Betül Yerer, and Anupam Bishayee, “Resveratrol and diabetes: A critical review of clinical studies,” Biomedicine & Pharmacotherapy, vol. 95, pp. 230–234, 2017. View at Publisher · View at Google Scholar
  • Paola M. Hunter, and Robert A. Hegele, “Functional foods and dietary supplements for the management of dyslipidaemia,” Nature Reviews Endocrinology, vol. 13, no. 5, pp. 278–288, 2017. View at Publisher · View at Google Scholar
  • Ojha Rakesh, Kulkarni Pranesh, and Vyas Bhavin, “A randomized active controlled clinical study to evaluate efficacy and safety of resveratrol as an adjuvant therapy in patients with hypertension,” Asian Journal of Pharmaceutical and Clinical Research, vol. 10, no. 1, pp. 376–379, 2017. View at Publisher · View at Google Scholar
  • Joshua A. David, William J. Rifkin, Piul S. Rabbani, and Daniel J. Ceradini, “The Nrf2/Keap1/ARE Pathway and Oxidative Stress as a Therapeutic Target in Type II Diabetes Mellitus,” Journal of Diabetes Research, vol. 2017, pp. 1–15, 2017. View at Publisher · View at Google Scholar
  • J. Luis Espinoza, Ly Quoc Trung, Pleiades T. Inaoka, Kayoko Yamada, Dao T. An, Shohei Mizuno, Shinji Nakao, and Akiyoshi Takami, “The Repeated Administration of Resveratrol Has Measurable Effects on Circulating T-Cell Subsets in Humans,” Oxidative Medicine and Cellular Longevity, vol. 2017, pp. 1–10, 2017. View at Publisher · View at Google Scholar