Repeated-Doses Toxicity Study of the Essential Oil of Hyptis martiusii Benth. (Lamiaceae) in Swiss Mice

Table 3

Effect of the essential oil of Hyptis martiusii (EOHM, 100 and 500 mg/kg) on biochemical parameters in male and female Swiss mice treated orally for 30 days.

Parameter	Control		EOHM 100 mg/kg		EOHM 500 mg/kg
	Male	Female	Male	Female	Male	Female
Glucose (mg/dL)	105.20±4.70	104.40±5.46	88.57±6.62	98.00±13.95	107.40±4.62	91.33±9.46
BUN (mg/dL)	47.17±4.44	41.41±4.99	49.17±5.52	49.68±2.36	48.87±3.41	34.83±3.53
Creatinine (mg/dL)	0.22±0.03	0.21±0.02	0.24±0.04	0.22±0.03	0.28±0.02	0.22±0.02
AST (U/L)	75.67±3.46	89.30±19.05	84.00±7.31	126.20±39.83	74.40±5.73	107.20±15.45
ALT (U/L)	10.67±0.88	14.71±0.92	12.71±1.94	20.50±6.46	15.29±3.91	22.67±2.03
Total cholesterol (mg/dL)	179.80±11.70	102.10±13.86	171.30±13.30	131.20±20.78	155.50±12.33	121.10±8.48
Triglycerides (mg/dL)	136.20±8.54	151.20±18.60	156.90±8.56	159.80±10.08	109.70±7.68	112.60±8.15
Total protein (g/dL)	6.00±0.13	5.20±0.17	5.88±0.21	4.98±0.23	5.83±0.21	5.70±0.09
Albumin (g/dL)	3.83±0.13	3.24±0.13	3.64±0.18	3.40±0.14	3.53±0.18	4.02±0.14^∗
HDL (U/L)	211.80±10.89	193.40±30.46	207.70±13.22	279.80±81.40	255.92±28.87	260.80±27.01

BUN: blood urea nitrogen, AST: aspartate aminotransferase, ALT: alanine aminotransferase, and HDL: lactate dehydrogenase. Values represent the mean ± SEM (𝑛=10/group). *Statistically different from the control group (ANOVA followed by Dunnett's test, 𝑃<0.05).