Research Article
Induction of Apoptosis and Cell Cycle Blockade by Helichrysetin in A549 Human Lung Adenocarcinoma Cells
Table 1
IC50 values of helichrysetin and doxorubicin on selected cancer cells.
| | Cells | Type | Helichrysetin | Doxorubicin | | IC50 (μM) | IC50 (μM) |
| | A549 | Lung adenocarcinoma | 50.72 ± 1.26 (14.52 ± 0.36 μg/mL) | 1.10 ± 0.02 (0.19 ± 0.01 μg/mL) | | Ca Ski | Cervical carcinoma | 31.02 ± 0.45 (8.88 ± 0.13 μg/mL) | 0.35 ± 0.02 (0.07 ± 0.01 μg/mL) | | HT-29 | Colon adenocarcinoma | 102.94 ± 2.20 (27.87 ± 0.49 μg/mL) | 0.48 ± 0.08 (0.60 ± 0.01 μg/mL) | | MCF-7 | Breast adenocarcinoma | 97.35 ± 1.71 (29.47 ± 0.63 μg/mL) | 0.13 ± 0.02 (0.26 ± 0.04 μg/mL) |
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IC50: concentration that causes 50% of cell growth inhibition. Results are shown as mean ± S.E. from three independent experiments.
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