Active Constituents from Liriope platyphylla Root against Cancer Growth In Vitro

Figure 5

Involvement of p53 in LPRP-9-induced cell death. MCF-7 and Huh-7 were treated with indicated doses of doxorubicin or LPRP-9 for 24 h. (a) Immunoblots results showing p53 activation by detection levels of phosphor-p53 Ser¹⁵ and p53 protein. (b) Effects of pifithrin-α on doxorubicin or LPRP-9 induced-cell death by detecting cell viability using MTT assay at 24 h of drugs incubation. 𝑁=3. *𝑃<0.05 compared with null control within group.

(a)

(b)