Evidence-Based Complementary and Alternative Medicine / 2013 / Article / Tab 1

Review Article

Differentiated Evaluation of Extract-Specific Evidence on Cimicifuga racemosa's Efficacy and Safety for Climacteric Complaints

Table 1

Inclusion, exclusion, and stratification criteria for the identification of the literature for the evaluation of the efficacy and safety of Cimicifuga racemosa.

EfficacyGeneral safetySafety in estrogen-sensitive organs Liver safety

Inclusion criteria
(1) Medical application of Black Cohosh++++
(2) 3-month treatment period at a minimum+
(3) Full publication of clinical studies++++
(4) Efficacy in natural climacteric complaints (neurovegetative, psychic)+
(5) Occurrence and frequency of adverse events +++
(6) Influence on hormone parameters, breast, and uterus +
(7) Influence on liver function parameters+

Exclusion criteria
(1) Preparations containing more than two ingredients++++
(2) Medication-induced complaints (e.g., tamoxifen)+
(3) Use outside the registered indication (bone metabolism, anxiety disorder, and cognition)++++
(4) Prevention, including tertiary prevention of sequelae+
(5) Publications in languages other than English/German++++

Stratification criteria
(1) Sorting by type of extract++++
(2) Differentiation between registered medicinal products versus other products ++++