The Effects of N-Butyl-1-(4-dimethylamino)phenyl-1,2,3,4-tetrahydro-β-carboline-3-carboxamide against Leishmania amazonensis Are Mediated by Mitochondrial Dysfunction
Figure 5
Mitochondrial production in promastigote forms of Leishmania amazonensis treated with C4 for up to 3 h. Mitochondrial production was evaluated using the fluorescent probe MitoSOX. At the indicated times, promastigotes were used to measure oxidized MitoSOX (oxMitoSOX). The results are expressed in arbitrary units (mean ± SE of at least three independent experiments). , significant difference compared with the control group (i.e., untreated cells; two-way analysis of variance followed by Tukey post hoc test).
