Xiao-Ai-Ping, a TCM Injection, Enhances the Antigrowth Effects of Cisplatin on Lewis Lung Cancer Cells through Promoting the Infiltration and Function of CD8⁺ T Lymphocytes

Figure 1

Cisplatin dose-dependently inhibited the growth of LLC xenografts while Xiao-Ai-Ping had little effect. Various doses of cisplatin (Cis, 0.25, 0.5, 1 mg/kg, 𝑛=8 per group) or Xiao-Ai-Ping (Xiao, 10, 20 g crude/kg 𝑛=8 per group) were daily i.p. injected to LLC-bearing mice, respectively, for 12 days. Body weight and tumor volumes were measured every three days. (a–d) Tumor volumes (a), tumor weight (b), body weight (c), and spleen weight (d) of cisplatin-treated LLC-bearing mice. (e–h) Tumor volumes (e), tumor weight (f), body weight (g), and spleen weight (h) of Xiao-Ai-Ping treated LLC-bearing mice. *𝑃<0.05, **𝑃<0.01, ***𝑃<0.001 versus vehicle (PBS). LLC, Lewis lung cancer.

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