Melatonin Suppresses the Expression of 45S Preribosomal RNA and Upstream Binding Factor and Enhances the Antitumor Activity of Puromycin in MDA-MB-231 Breast Cancer Cells

Figure 1

Cytotoxicity of melatonin and puromycin in MDA-MB-231 breast cancer cells. Various concentrations of melatonin (0, 1, 2, 4, 8, or 16 mM) (a) or puromycin (0, 0.5, 1, 2, 4, or 8 μM/mL) (b) were treated in MDA-MB-231 cells for 24 h, and then cell viability was determined by MTT assay. The data were expressed as means ± SD. ^∗𝑃<0.05, ^∗∗𝑃<0.01, ^∗∗∗𝑃<0.001 versus untreated control.

(a)

(b)