Bee Venom Mitigates Cisplatin-Induced Nephrotoxicity by Regulating CD4+CD25+Foxp3+ Regulatory T Cells in Mice
Figure 7
The number of Foxp3-positive cells in the kidney. Tregs in the kidney were detected by EGFP signal under the confocal microscope imaging. Foxp3-positive cells were indicated by arrows (a). There was no difference in the number of Foxp3 positive cells between PBS-treated group and BV-treated group before cisplatin administration. However, Foxp3-positive cells in the kidney increased 6 hours after cisplatin administration. In BV-pretreated group, after cisplatin administration, the number of Foxp3-positive cells in the kidney was significantly higher than in PBS-pretreated group (b). All data are presented as the mean ± SEM. NS, , versus cont, and versus Cis, as determined by one-way ANOVA followed by Tukey’s multiple comparison test.
