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Evidence-Based Complementary and Alternative Medicine
Volume 2013, Article ID 890579, 7 pages
Research Article

Gene Expression Profiles at Moxibustioned Site (ST36): A Microarray Analysis

1Acupuncture & Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China
2Joint Laboratory of Biochip between Chengdu University of Traditional Chinese Medicine and CapitalBio Co. Ltd., 37 Shi-er Qiao Road, Chengdu 610075, China
3Key Laboratory for Acupuncture & Chronobiology of Sichuan Province, Chengdu 610075, China
4Acupuncture & Tuina School, Nanjing University of Traditional Chinese Medicine, Nanjing 210029, China
5Laboratory for Acupuncture & Systematic Biology, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China

Received 6 June 2013; Accepted 2 July 2013

Academic Editor: Yong-Qing Yang

Copyright © 2013 Hai-Yan Yin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


As a major alternative therapy in Traditional Chinese Medicine, it has been demonstrated that moxibustion could generate a series of molecular events in blood, spleen, and brain, and so forth. However, what would happen at the moxibustioned site remained unclear. To answer this question, we performed a microarray analysis with skin tissue taken from the moxibustioned site also Zusanli acupoint (ST36) where 15-minute moxibustion stimulation was administrated. The results exhibited 145 upregulated and 72 downregulated genes which responded immediately under physiological conditions, and 255 upregulated and 243 downregulated genes under pathological conditions. Interestingly, most of the pathways and biological processes of the differentially expressed genes (DEGs) under pathological conditions get involved in immunity, while those under physiological conditions are involved in metabolism.