Figure 2: PC-SPESII inhibits pulmonary metastasis of MDA-MB-231 cells in Balb/c mice. Mice were divided into three experimental groups and were given drugs by oral gavage. The experiment was terminated 8 weeks after the initiation of therapy. Lungs were removed and fixed with Bouin’s solution for 24 hours. Metastatic lesions on the lungs were counted under a dissecting microscope (100x magnification). (a) Histological appearances of representative lungs from normal, saline-treated, and PC-SPESII-treated mice are shown. (b) Quantification of metastatic lung nodules. (c) Tumor weights in grams of animals with different treatments were measured. ** compared to the saline group.