A Preclinical Evaluation of Antimycin A as a Potential Antilung Cancer Stem Cell Agent
Figure 1
Identification of antimycin A as a potential anti-CSC agent using the connectivity maps database. Gene set enrichment analysis (GSEA) demonstrated that the AMA drug signature reverses Wong’s ESC module (a) and the Myc module from Kim’s study (b). Both modules have been correlated with CSC-like phenotypes, suggesting antimycin A have the potential to reverse lung CSC signature.
