Therapeutic Effect of C-Phycocyanin Extracted from Blue Green Algae in a Rat Model of Acute Lung Injury Induced by Lipopolysaccharide

Figure 3

Effects of CPC on superoxide production and nitrotyrosine expression in lungs and NO_x formation in BALF in LPS-induced ALI rats. Rats were administrated with CPC (50 mg/kg, i.p.) 3 h after LPS was instilled intratracheally. BALF was prepared from rats 6 h after LPS challenge, and the level of NO_𝑥 was determined (a). Lung homogenates were used to measure superoxide production (b) and nitrotyrosine expression (c). Data are presented as the mean ± SEM (𝑛=5). ***𝑃<0.001 compared with control group; ^##𝑃<0.01, ^###𝑃<0.001 compared with LPS group.

(a)

(b)

(c)