Ursolic-Acid-Enriched Herba Cynomorii Extract Protects against Oxidant Injury in H9c2 Cells and Rat Myocardium by Increasing Mitochondrial ATP Generation Capacity and Enhancing Cellular Glutathione Redox Cycling, Possibly through Mitochondrial Uncoupling
Figure 7
Effect of HCY2/UA pretreatment on myocardial I/R injury in male and female rats ex vivo. Animals were orally treated with vehicle (olive oil) or HCY2/UA (at the indicated doses) for 14 consecutive days. Isolated hearts were subjected to I/R challenge as described in Section 2. The extent of tissue injury was assessed by the measurement of LDH leakage. Each bar represents mean ± SEM, with . “*” significantly different from the non-I/R control; “#” significantly different from I/R-challenged control.
