Evaluation of the Genotoxic Potential against H_𝟐O_𝟐-Radical-Mediated DNA Damage and Acute Oral Toxicity of Standardized Extract of Polyalthia longifolia Leaf

Table 4

Effect of single oral administration of the extract on biochemical parameter in SD rat.

Biochemistry parameters	Unit	Acute oral toxicity
		Control	Test sample
			175 mg/kg
Sodium	mmol/L	157.2 ± 3.4	148.2 ± 6.1
Potassium	mmol/L	23.4 ± 1.5	18.9 ± 1.3
Chloride	mmol/L	164.8 ± 10.3	182.6 ± 1.95
Urea	mmol/L	9.31 ± 2.04	11.07 ± 0.51
Creatinine	umol/L	26.84 ± 2.49	31.5 ± 1.9
Uric acid	mmol/L	0.46 ± 0.03	0.39 ± 0.04
Total Protein	g/L	93.4 ± 4.09	88.8 ± 2.82
Albumin	g/L	37.05 ± 2.36	42.3 ± 3.17
Globulin	g/L	77.1 ± 4.33	69.6 ± 4.71
Albumin/globulin ratio		0.61 ± 0.1	0.58 ± 0.04
Alkaline phosphatase	U/L	347.61 ± 52.14	287.2 ± 24.5
Total bilirubin	umol/L	<1 ± 0	<1 ± 0
(GGT) gamma glutamyl transferase	U/L	<2 ± 0	<2 ± 0
AST aspartate aminotransferase	U/L	1461.3 ± 147.2	1282.1 ± 247.2
ALT Alanine aminotransferase	U/L	320.2 ± 128.52	289.4 ± 118.7
Total cholesterol	mmol/L	7.1 ± 1.4	5.2 ± 0.81
LDL	mmol/L	2.03 ± 0.07	1.22 ± 0.8
HDL	mmol/L	1.18 ± 0.03	1.46 ± 0.08
Triglyceride	mmol/L	5.08 ± 1.4	3.77 ± 0.9