Effects and Mechanisms of Chinese Herbal Medicine in Ameliorating Myocardial Ischemia-Reperfusion Injury

Table 3

Efficacy and mechanisms of Chinese herb decoctions in the treatment of MIR.

Mechanism of action in TCM terminology	Decoction	Constituent herbs	Mechanism	Biomarker/Targets	In vivo/In vitro	References
Tonifying Qi to enrich Blood	DangGui BuXue Decoction	Astragali and Angelica roots	Antioxidant, protect mitochondrial function	GSH, GSSG, GRD	In vivo	[108]
	BuYang HuanWu Decoction	Astragalus, angelica, red peony, earthworm, and so forth	Reduce ME	LDH, CK, AST; CD40-CD40L	In vivo	[109]
Replenishing Qi to activate Blood and recover circulation	ShuMai Decoction	Astragalus mongholicus, Salvia miltiorrhiza, Eupolyphaga,; Wallich and Hirudo nipponica Whitman, Moschus berezovskii	Anti-inflammation	TNF-α, p38, MAPK, TIMP-1	In vivo	[58]
			Promote angiogenesis	VEGF, PDGF-BB, PI3K, Akt	In vivo	[110]
Invigorating Yang to recover circulation	Sini Decoction	Aconite, ginger, and licorice	Antimitochondrial oxidation	SOD, MDA, MnSOD mRNA	In vivo	[54]
Moving Qi to activate circulation	Dan-Chuan-Hong Decoction	Salvia, Rhizoma Chuanxiong, and safflower	Anti-apoptosis	TUNEL	In vivo	[111]
Enriching Blood to engender fluid	DanShen GeGen Decoction	Radix Salvia miltiorrhiza, and Radix Puerariae lobatae	Antioxidant	Redox-sensitive PKCε/mKATP pathway	In vivo	[112]
Enrich Qi and cool Blood	Radix et Rhizoma Rhodiolae Kirilowii	Radix, Rhizoma Rhodiolae kirilowii	Promote angiogenesis	vWF, VEGF, HIF-1α, HIF-1β	In vivo	[69]