Evidence-Based Complementary and Alternative Medicine / 2013 / Article / Tab 3

Review Article

Effects and Mechanisms of Chinese Herbal Medicine in Ameliorating Myocardial Ischemia-Reperfusion Injury

Table 3

Efficacy and mechanisms of Chinese herb decoctions in the treatment of MIR.

Mechanism of action in TCM terminologyDecoctionConstituent herbsMechanismBiomarker/TargetsIn vivo/In vitroReferences

Tonifying Qi to enrich Blood DangGui BuXue Decoction Astragali and Angelica rootsAntioxidant, protect mitochondrial functionGSH, GSSG, GRDIn vivo [108]
BuYang HuanWu Decoction Astragalus, angelica, red peony, earthworm, and so forthReduce ME LDH, CK, AST; CD40-CD40LIn vivo[109]

Replenishing Qi to activate Blood and recover circulationShuMai Decoction Astragalus mongholicus, Salvia miltiorrhiza, Eupolyphaga,
Wallich and Hirudo nipponica Whitman, Moschus berezovskii
Anti-inflammationTNF-α, p38, MAPK, TIMP-1In vivo[58]
Promote angiogenesisVEGF, PDGF-BB, PI3K, AktIn vivo[110]
Invigorating Yang to recover circulationSini Decoction Aconite, ginger, and licoriceAntimitochondrial oxidationSOD, MDA, MnSOD mRNAIn vivo[54]

Moving Qi to activate circulationDan-Chuan-Hong Decoction Salvia, Rhizoma Chuanxiong, and safflowerAnti-apoptosisTUNELIn vivo[111]
Enriching Blood to engender fluidDanShen GeGen Decoction Radix Salvia miltiorrhiza, and Radix Puerariae lobataeAntioxidantRedox-sensitive PKCε/mKATP pathwayIn vivo[112]

Enrich Qi and cool Blood Radix et Rhizoma Rhodiolae Kirilowii Radix, Rhizoma Rhodiolae kirilowiiPromote angiogenesisvWF, VEGF, HIF-1α, HIF-1βIn vivo[69]

We are committed to sharing findings related to COVID-19 as quickly as possible. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Review articles are excluded from this waiver policy. Sign up here as a reviewer to help fast-track new submissions.