Efficacy and Safety of Echinacoside in a Rat Osteopenia Model
Table 2
BMD, Micro-CT properties of femoral trabeculae and biomechanical test of femur after 12-week administration of ECH.
Group
SHAM
OVX
E2
ECH-L
ECH-M
ECH-H
BMD (g/cm2)
0.28 ± 0.01
0.22 ± 0.01##
0.26 ± 0.01**
0.25 ± 0.01**
0.26 ± 0.01**
0.28 ± 0.01**
BV/TV (%)
58.71 ± 6.38
16.42 ± 3.44##
34.52 ± 3.38**
23.22 ± 4.07*
26.12 ± 2.02**
28.80 ± 2.53**
Tb.N (1/mm)
3.88 ± 0.25
2.18 ± 0.48##
3.01 ± 0.10*
2.76 ± 0.58
3.02 ± 0.38*
3.12 ± 0.41*
Tb.Sp (μm)
106.52 ± 14.78
452.02 ± 65.48##
219.83 ± 9.99**
355.04 ± 41.53*
321.98 ± 28.59*
279.57 ± 23.15**
Tb.Th (μm)
152.28 ± 22.30
84.05 ± 7.19##
114.24 ± 8.13**
97.12 ± 7.47*
112.06 ± 20.16*
115.32 ± 10.79**
SMI
0.78 ± 0.12
2.77 ± 0.49##
1.41 ± 0.25**
2.11 ± 0.15*
1.90 ± 0.43*
1.86 ± 0.17*
Maximum load (N)
87.54 ± 5.86
60.00 ± 3.35##
89.71 ± 6.45**
83.05 ± 7.81**
83.70 ± 6.49**
93.31 ± 13.66**
Stiffness (N/mm)
190.98 ± 36.03
147.56 ± 12.54#
189.81 ± 18.33**
173.17 ± 24.52*
178.67 ± 18,55**
197.79 ± 32.05**
Energy to ultimate load (millijoules, mJ)
17.33 ± 2.58
12.00 ± 1.79##
18.67 ± 3.01**
25.67 ± 2.88**
25.83 ± 3.13**
34.00 ± 4.65**
The data are expressed as mean ± SD, n = 6. #P < 0.05 and ##P < 0.01 versus SHAM group, *P < 0.05 and **P < 0.01 versus OVX group at the same time point as evaluated by ANOVA.
