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Evidence-Based Complementary and Alternative Medicine
Volume 2013, Article ID 930857, 10 pages
Research Article

Topical Administration of Manuka Oil Prevents UV-B Irradiation-Induced Cutaneous Photoaging in Mice

1Department of Integrative Medicine, Korea University Medical School, 126-1 Anam-Dong, Sungbuk-Gu, Seoul 136-705, Republic of Korea
2Chemical Kinomics Research Center, Korea Institute of Science and Technology, 39-1 Hawolgok-Dong, Sungbuk-Gu, Seoul 136-791, Republic of Korea

Received 21 February 2013; Revised 1 May 2013; Accepted 8 May 2013

Academic Editor: Ki-Wan Oh

Copyright © 2013 Oh Sook Kwon et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Manuka tree is indigenous to New Zealand, and its essential oil has been used as a traditional medicine to treat wounds, fever, and pain. Although there is a growing interest in the use of manuka oil for antiaging skin care products, little is known about its bioactivity. Solar ultraviolet (UV) radiation is the primary environmental factor causing skin damage and consequently premature aging. Therefore, we evaluated manuka oil for its effects against photoaging in UV-B-irradiated hairless mice. Topical application of manuka oil suppressed the UV-B-induced increase in skin thickness and wrinkle grading in a dose-dependent manner. Application of 10% manuka oil reduced the average length, depth, and % area of wrinkles significantly, and this was correlated with inhibition of loss of collagen fiber content and epidermal hyperplasia. Furthermore, we observed that manuka oil could suppress UV-B-induced skin inflammation by inhibiting the production of inflammatory cytokines. Taken together, this study provides evidence that manuka oil indeed possesses antiphotoaging activity, and this is associated with its inhibitory activity against skin inflammation induced by UV irradiation.