Eleutheroside E, An Active Component of Eleutherococcus senticosus, Ameliorates Insulin Resistance in Type 2 Diabetic db/db Mice

Table 2

The effect of ES and EE on the lipid profile of db/db mice.

	DM	ESL	ESH	EE
Total cholesterol (mg/dL)	375.11 ± 74.79	238.19 ± 86.42*	247.29 ± 45.91*	330.59 ± 21.17
Triglyceride (mg/dL)	180.24 ± 57.19	137.89 ± 35.77	113.93 ± 20.17*	112.35 ± 29.75*
FFA (uEq/L)	1412.78 ± 74.28	1080.16 ± 160.21*	1190.08 ± 102.30	1072.38 ± 269.91*
Glucose (mg/dL)	486 ± 21.53	397.8 ± 29.30*	389.2 ± 21.24*	315.0 ± 24.67*
Insulin (ng/mL)	8 ± 1.8	2.81 ± 0.71*	4.28 ± 1.29*	3.56 ± 0.41*
HOMA-IR	75.89 ± 13.64	36.49 ± 12.22*	42.79 ± 15.95*	33.5 ± 6.63*

All values are expressed as the mean ± SEM. Six-week-old db/db mice were fed experimental diet containing none, 0.05–0.01 % E. senticosus (ES) extract, and 0.1% eleutheroside E (EE) for 5 weeks.
DM: diabetes mellitus group; ESL: 0.05% ES extract supplemented group; ESH: 0.1% ES extract supplemented group; EE: 0.003% eleutheroside E supplemented group.
∗P < 0.05 when compared to the DM group using one-way ANOVA followed by post hoc Bonferroni’s tests.