| Disease types | TCM | Effective molecule | Target | Reference* |
| Anti-inflammation | Rhizoma atractylodis macrocephalae | AtractylenolideI | IL1B, iNOS, PTGS1, PTGS2, SRC | | Rhizoma atractylodis macrocephalae | AtractylenolideIII | iNOS | | Radix glycyrrhiza | Isoliquiritigenin | MIF, PTGS2, | [8] | Radix glycyrrhiza | licochalcone A | iNOS, PTGS1, PTGS2, | | Radix glycyrrhiza | Ononin | ALOX5, CD46, MIF, iNOS, PTGS1, PTGS2, RXRA | | Rradix astragali | Calycosin | ALOX5, MIF, HCK | [6, 7, 42, 73] | Rradix astragali | Isoflavanone | IDO1, PTGS1, | | Ginseng | Ginsenoside-Rb1 | IL1B, NFKBIA, PRKCB | [43] | Ginseng | Ginsenoside-Re | iNOS | | Ginseng | Ginsenoside-Rf | IFNG, IL1B, IL4, PTGS2 | | Ginseng | Ginsenoside-Rg1 | IL2, IL4, PRKCB | | Ginseng | Ginsenoside-Rg3 | IFNG, IL1B, IL4, iNOS, PTGS2 | | Dioscorea opposite | Batatasin I | HCK | | Dioscorea opposite | Diosgenin-3-O-beta-D-glucopyranoside | PTGS2 | | Panax quinquefolium | Pseudostellaria G | GRB2, ITGA4, | |
| CVD | Rhizoma atractylodis macrocephalae | Atractylone | ADRB1, ADRA1A, ADRA1B, SCN5A | | Rhizoma atractylodis macrocephalae | AtractylenolideI | F13A1, ALAD, PGF, VEGFA | | Radix glycyrrhiza | Isoliquiritigenin | SELEa, F11Rb, JAK2c, VCAM1, PTGS1, | [53] | Radix glycyrrhiza | licochalcone A | ADRA1B, FOSL2, SCN5A, HDAC5, HDAC9, CHRM1, | | Radix glycyrrhiza | Ononin | KDR, PIK3CG, | | Rradix astragali | Isoflavanone | ALOX15, | | Rradix astragali | Calycosin | PI3K-beta, ABL1, PIK3CG, ALOX15, PIK3CG | | Ginseng | Ginsenoside-Ra1 | PTPN2 | [52] | Ginseng | Ginsenoside-Rb1 | PTPN2, VEGFA, VCAM1 | | Ginseng | Ginsenoside-Rb2 | PTPN2 | | Ginseng | Ginsenoside-Rd | PTPN2 | | Ginseng | Ginsenoside-Rg3 | MMP9, | | Ginseng | Ginsenoside-Re1 | TSP1 | | Ginseng | Ginsenoside-Rg1 | ACTA2, PTPN2 | | Dioscorea opposite | Batatasin I | PI3K-beta, ALOX15 | | Dioscorea opposite | Diosgenin-3-O-beta-D-glucopyranoside | HIF1A, VEGFA, PLA2G4A | | Panax quinquefolium | Pseudostellaria G | FNRB, ITGA2B | [74] |
| Metabolic process | Rhizoma atractylodis macrocephalae | Atractylone | PDE3A | | Rhizoma atractylodis macrocephalae | AtractylenolideI | GPT, ADH1C, AR, ASS1, ASPC, GATM, PLA2G2E, IDH1, ME2, PTER, TPI1, PRSS1, PRSS3 | | Radix glycyrrhiza | Isoliquiritigenin | PRKACA, PKIA, METAP1, PPAR-gamma | [75] | Radix glycyrrhiza | licochalcone A | CALM, EIF6, GCGR, GSK3B, MAPK14, PPAR-gamma, PRSS1 | | Radix glycyrrhiza | Ononin | CALM, PRKACA, PKIA, PDE3A, HSD17B3, GSK3B, GLO1, MCHR1, PPAR-gamma, PRSS1 | | Rradix astragali | Calycosin | HSD17B3, GLO1, MCHR1 | [76] | Ginseng | Ginsenoside-Rb1 | GSK3B | [61] | Ginseng | Ginsenoside-Rg3 | PRKAG2, PPAR-gamma | | Dioscorea opposite | Diosgenin-3-O-beta-D-glucopyranoside | HSD17B3, FAS, NR1I2, AKT1, MTOR AKT1, MTOR | [77] | Dioscorea opposite | ergosterol | DHCR7b | | Panax quinquefolium | Pseudostellaria G | OPRM1 | [78] |
| Anticancer | Rhizoma atractylodis macrocephalae | AtractylenolideI | CTSD, TNF, SRC, | | Rhizoma atractylodis macrocephalae | AtractylenolideIII | TNF | | Radix glycyrrhiza | licochalcone A | CDK4, CCND1b, RB1, RELA, CHEK1, STAT3d, HDAC9 | | Radix glycyrrhiza | Isoliquiritigenin | HDAC1, HDAC2, HDAC3, HDAC5, HDAC9, SLC2A1, FOSb | | Radix glycyrrhiza | Ononin | CHEK1, RET | | Rradix astragali | Calycosin | CDK4, TERT, RET, CHEK1 | [10] | Ginseng | Ginsenoside-Rf | TNF | [68] | Ginseng | Ginsenoside-Rg1 | SMAD2, FN1, TGFB1 | | Ginseng | Ginsenoside-Rc | FOS | | Ginseng | Ginsenoside-Re | FOS | | Ginseng | Ginsenoside-Rg3 | TNF | | Panax quinquefolium | Pseudostellaria G | CXCR4, HDAC1, HDAC2, HDAC3, HDAC5, HDAC9, ITGA6 | | Dioscorea opposite | Batatasin I | PDGFRA | | Dioscorea opposite | Diosgenin-3-O-beta-D-glucopyranoside | CAT, TP53, SHH, RELA | |
| CNS diseases | Rhizoma atractylodis macrocephalae | AtractylenolideI | AChE, BCHE, GABRA1, GLRA1, Nos1, ABAT, | [71] | Rhizoma atractylodis macrocephalae | AtractylenolideII | AChE, GABRA1, GABRA1, GABRA1, GRIA2, CHRNA7 | | Rhizoma atractylodis macrocephalae | AtractylenolideIII | AChE, GABRA1, GABRA1, GRIA2, CHRNA7 | | Rhizoma atractylodis macrocephalae | Atractylone | DRD1, HTR2A, CHRNA7, SLC6A3, SLC6A2, CHRM1, CHRM2, CHRM3, CHRM4 | | Radix glycyrrhiza | Isoliquiritigenin | HSP90AA1, MAOB, KCNA3, APP, MAPK14, | | Radix glycyrrhiza | licochalcone A | HSP90AA1, MAOB, SLC6A3, KCNA3, MPK1, APP, | | Radix glycyrrhiza | Ononin | HSP90AA1, MAOA, MAOB, NQO1, SLC6A2, MAPK14, | | Rradix astragali | Calycosin | MAOA, MAOB, NQO1, CD46 | | Rradix astragali | isoflavanone | MAOA, MAOB, NQO1, SIGMAR1, CD46, MT-ND1, MT-ND2, MT-ND3, MT-ND4, MT-ND4L, MT-ND5, MT-ND6 | | Ginseng | Ginsenoside-Rb1 | PLAT, | | Ginseng | Ginsenoside-Rg3 | HTR3A | | Panax quinquefolium | Pseudostellaria G | OPRD1, OPRK1 | |
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