A Phenylbutenoid Dimer, <i>cis</i>-3-(3′,4′-Dimethoxyphenyl)-4-[(<i>E</i>)-3′′′,4′′′-Dimethoxystyryl] Cyclohex-1-ene, Exhibits Apoptogenic Properties in T-Acute Lymphoblastic Leukemia Cells via Induction of p53-Independent Mitochondrial Signalling Pathway

<table>Normal phase contrast inverted micrograph of CEMss cells treated withZC-B11 (IC<sub>50</sub>) for 24, 48, and 72 h. (a) Control, (b) most of the cells exhibit normal morphology while some cells show cytoplasmic protrusions (24 h), (c) clear apoptogenic morphology such as blebbing and cell shrinkage observed (48 h), and (d) prominent growth inhibition, blebbing of the cell membrane, and shrinkage of cells observed (72 h). BL: blebbing of the cell membrane; CS: cell shrinkage (400x magnification).</table>

Evidence-Based Complementary and Alternative Medicine

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Figure 2

Figure 2: A Phenylbutenoid Dimer, <i>cis</i>-3-(3′,4′-Dimethoxyphenyl)-4-[(<i>E</i>)-3′′′,4′′′-Dimethoxystyryl] Cyclohex-1-ene, Exhibits Apoptogenic Properties in T-Acute Lymphoblastic Leukemia Cells via Induction of p53-Independent Mitochondrial Signalling Pathway 

Figure 2 | A Phenylbutenoid Dimer, cis-3-(3′,4′-Dimethoxyphenyl)-4-[(E)-3′′′,4′′′-Dimethoxystyryl] Cyclohex-1-ene, Exhibits Apoptogenic Properties in T-Acute Lymphoblastic Leukemia Cells via Induction of p53-Independent Mitochondrial Signalling Pathway 