A Phenylbutenoid Dimer, cis-3-(3′,4′-Dimethoxyphenyl)-4-[(E)-3′′′,4′′′-Dimethoxystyryl] Cyclohex-1-ene, Exhibits Apoptogenic Properties in T-Acute Lymphoblastic Leukemia Cells via Induction of p53-Independent Mitochondrial Signalling Pathway
The bioluminescent assay of caspases 3/7 (a), 8 (b), and 9 (c) in CEMss cells treated with ZC-B11 (IC50) after 24, 48, and 72 hours of treatment. Untreated cells serve as negative control. (a), (c) Caspase 3/7 and 9 activities increased significantly (*) compared to untreated control; (b) Caspase 8 activity remained at the basal level throughout the treatment period. Results were represented as means ± SD for three independent experiments.