A Phenylbutenoid Dimer, <i>cis</i>-3-(3′,4′-Dimethoxyphenyl)-4-[(<i>E</i>)-3′′′,4′′′-Dimethoxystyryl] Cyclohex-1-ene, Exhibits Apoptogenic Properties in T-Acute Lymphoblastic Leukemia Cells via Induction of p53-Independent Mitochondrial Signalling Pathway

<table>The bioluminescent assay of caspases 3/7 (a), 8 (b), and 9 (c) in CEMss cells treated with ZC-B11 (IC<sub>50</sub>) after 24, 48, and 72 hours of treatment. Untreated cells serve as negative control. (a), (c) Caspase 3/7 and 9 activities increased significantly (*<svg height="11.375" id="M39" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 58.712502 11.375" width="58.712502" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>) compared to untreated control; (b) Caspase 8 activity remained at the basal level throughout the treatment period. Results were represented as means ± SD for three independent experiments. </table>

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fig9

Figure 9

Figure 9: A Phenylbutenoid Dimer, <i>cis</i>-3-(3′,4′-Dimethoxyphenyl)-4-[(<i>E</i>)-3′′′,4′′′-Dimethoxystyryl] Cyclohex-1-ene, Exhibits Apoptogenic Properties in T-Acute Lymphoblastic Leukemia Cells via Induction of p53-Independent Mitochondrial Signalling Pathway 

Figure 9 | A Phenylbutenoid Dimer, cis-3-(3′,4′-Dimethoxyphenyl)-4-[(E)-3′′′,4′′′-Dimethoxystyryl] Cyclohex-1-ene, Exhibits Apoptogenic Properties in T-Acute Lymphoblastic Leukemia Cells via Induction of p53-Independent Mitochondrial Signalling Pathway 