Trypanocidal Activity of Thioamide-Substituted Imidazoquinolinone: Electrochemical Properties and Biological Effects

Table 2

Effect of treatment with C1 on antioxidant enzymes activities.

Time of treatment (hours)	Drug (μM)	SOD activity (%)	APx activity (%)	TryR activity (%)
5	0	100.00±3.60	100.00±3.89	100.00±4.56
	7.5	95.85±2.50	111.26±7.60	152.23±6.38^∗
	15.0	99.31±4.30	98.31±2.10	177.17±15.56^∗
	22.5	90.09±2.30	105.20±6.20	143.89±4.80^∗
12	0	100.00±4.20	100.00±1.50	100.00±8.30
	7.5	99.75±2.90	98.30±2.30	188.60±12.30^∗
	15.0	103.92±4.30	95.91±4.10	251.62±15.56^∗
	22.5	88.48±3.20^∗	93.48±6.20	190.55±14.29^∗
24	0	100.00±4.50	100.00±4.22	100.00±6.30
	7.5	98.74±7.30	108.35±9.20	165.23±9.80^∗
	15.0	89.78±3.50^∗	105.30±6.56	198.27±9.30^∗
	22.5	78.27±4.20^∗	96.25±5.80	163.56±7.60^∗

Experimental conditions were as described in Section 2. For each time of treatment the activity value obtained in the absence of C1 was considered as the control value (100%). ∗Significant differences (𝑃>0.05) were found when compared to the control as assessed by Student’ t test.