Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2013 (2013), Article ID 956967, 10 pages
http://dx.doi.org/10.1155/2013/956967
Review Article

Understanding Acupuncture Based on ZHENG Classification from System Perspective

Center for Traditional Chinese Medicine and Systems Biology, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China

Received 30 July 2013; Revised 24 September 2013; Accepted 14 October 2013

Academic Editor: Shi-bing Su

Copyright © 2013 Junwei Fang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. T. T. Ma and F. R. Liang, “Acupuncture and its sophisticated effects,” World Science and Technology, vol. 10, no. 2, pp. 42–45, 2008. View at Google Scholar
  2. Y. Tang, S. G. Yu, X. G. Liu, Y. Li, H. Y. Yin, and F. R. Liang, “Discussion on research methods and ideas of meridians and acupoints specificity,” Journal of Chengdu University of TCM, vol. 30, no. 2, pp. 3–4, 2007. View at Google Scholar
  3. S. Li, Y. Y. Wang, L. Ji, and Y. D. Li, “A discussion and case study of complexities in Traditional Chinese Medicine,” Journal of System Simulation, vol. 14, no. 11, pp. 1429–1403, 2002. View at Google Scholar
  4. S. Li and Q. C. Zhang, “A second study on the relationship between TCM Qi and entrop theory,” Journal of Beijing University of TCM, vol. 20, no. 5, pp. 9–11, 1997. View at Google Scholar
  5. M. Zhang, “The influence of traditional culture on the formation of ZHENG theories in traditional Chinese medicine,” Henan Zhong Yi, vol. 31, no. 8, pp. 839–840, 2011. View at Google Scholar
  6. S. J. Sun, J. Y. Dai, and W. Y. Wang, “Metabonomic evaluation of ZHENG differentiation and treatment by Fuzhenghuayu tablet in hepatitis-B-caused cirrhosis,” Evidence-Based Complementary and Alternative Medicine, vol. 2012, Article ID 453503, 8 pages, 2012. View at Publisher · View at Google Scholar
  7. C. J. Li, Z. D. Gong, and J. H. Yan, “Researches on the essence of TCM ZHENG from the perspective of ZHENG model,” Journal of Traditional Chinese Medicine, vol. 52, no. 15, pp. 1267–1268, 2011. View at Google Scholar
  8. C. X. Li, “Discuss the essence of ZHENG,” Journal of Sichuan of Traditional TCM, vol. 29, no. 7, pp. 36–38, 2011. View at Google Scholar
  9. C. Auffray, Z. Chen, and L. Hood, “Systems medicine: the future of medical genomics and healthcare,” Genome Medicine, vol. 1, article 2, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. C. Lu, L. H. Zhao, C. Xiao et al., “Comparison of gene profile of peripheral CD4+ lymphocytes in rheumatoid arthritis,” Chinese Journal of Rheumatology, vol. 10, no. 7, pp. 438–439, 2006. View at Google Scholar
  11. C. Lu, C. Xiao, L. H. Zhao et al., “Comparison of gene profile of peripheral CD4+ lymphocytes in rheumatoid arthritis with cold and heat syndrome,” Chinese Journal of Basic Medicine in Traditional Chinese Medicine, vol. 12, no. 2, pp. 130–133, 2006. View at Google Scholar
  12. J. L. Liu, J. N. Song, Y. Lei et al., “Differential plasma protein profiles in patients with hyperlipidemia & atherosclerosis of different patterns of phlegm-stasis syndrome,” Chinese Journal of Integrated Traditional and Western Medicine, vol. 30, no. 5, pp. 482–487, 2010. View at Google Scholar
  13. W. J. Xu, L. X. Zhang, Y. H. Huang, Q. X. Yang, H. B. Xiao, and D. Q. Zhang, “Plasma fatty acid metabolic profiles for traditional Chinese medicine syndrome differentiation in diabetic patients using uncorrelated linear discriminant analysis,” Chinese Journal of Chromatography, vol. 30, no. 9, pp. 864–869, 2012. View at Google Scholar
  14. S. Li, Z. Q. Zhang, L. J. Wu, X. G. Zhang, Y. D. Li, and Y. Y. Wang, “Understanding ZHENG in traditional Chinese medicine in the context of neuro-endocrine-immune network,” IET Systems Biology, vol. 1, no. 1, pp. 51–60, 2007. View at Publisher · View at Google Scholar · View at Scopus
  15. C. Birkemeyer, A. Luedemann, C. Wagner, A. Erban, and J. Kopka, “Metabolome analysis: the potential of in vivo labeling with stable isotopes for metabolite profiling,” Trends in Biotechnology, vol. 23, no. 1, pp. 28–33, 2005. View at Publisher · View at Google Scholar · View at Scopus
  16. W. B. Dunn, A. Erban, R. J. M. Weber et al., “Mass appeal: metabolite identification in mass spectrometry-focused untargeted metabolomics,” Metabolomics, vol. 9, no. 1, pp. 44–66, 2013. View at Google Scholar
  17. Y.-Z. Gao, S.-Y. Guo, Q.-Z. Yin, T. Hisamitsu, and X.-H. Jiang, “An individual variation study of electroacupuncture analgesia in rats using microarray,” American Journal of Chinese Medicine, vol. 35, no. 5, pp. 767–778, 2007. View at Publisher · View at Google Scholar · View at Scopus
  18. H. J. Sung, Y. S. Kim, I. S. Kim et al., “Proteomic analysis of differential protein expression in neuropathic pain and electroacupuncture treatment models,” Proteomics, vol. 4, no. 9, pp. 2805–2813, 2004. View at Publisher · View at Google Scholar · View at Scopus
  19. Y. Y. Cai, Z. S. Liu, and B. Y. Liu, “Explore the issues of acupuncture research in clinical based on the result of systematic review,” Journal of Nanjing University of TCM, vol. 26, no. 4, pp. 245–248, 2010. View at Google Scholar
  20. Y.-G. Choi, S. Yeo, Y.-M. Hong, and S. Lim, “Neuroprotective changes of striatal degeneration-related gene expression by acupuncture in an MPTP mouse model of Parkinsonism: microarray analysis,” Cellular and Molecular Neurobiology, vol. 31, no. 3, pp. 377–391, 2011. View at Publisher · View at Google Scholar · View at Scopus
  21. Y.-G. Choi, S. Yeo, Y.-M. Hong, S.-H. Kim, and S. Lim, “Changes of gene expression profiles in the cervical spinal cord by acupuncture in an MPTP-intoxicated mouse model: microarray analysis,” Gene, vol. 481, no. 1, pp. 7–16, 2011. View at Publisher · View at Google Scholar · View at Scopus
  22. J. Ko, S. N. Doe, H. L. Young et al., “cDNA microarray analysis of the differential gene expression in the neuropathic pain and electroacupuncture treatment models,” Journal of Biochemistry and Molecular Biology, vol. 35, no. 4, pp. 420–427, 2002. View at Google Scholar · View at Scopus
  23. H.-S. Shiue, Y.-S. Lee, C.-N. Tsai, Y.-M. Hsueh, J.-R. Sheu, and H.-H. Chang, “Gene expression profile of patients with phadiatop-positive and -negative allergic rhinitis treated with acupuncture,” Journal of Alternative and Complementary Medicine, vol. 16, no. 1, pp. 59–68, 2010. View at Publisher · View at Google Scholar · View at Scopus
  24. Y. Chae, H.-J. Park, D.-H. Hahm, S.-H. Yi, and H. Lee, “Individual differences of acupuncture analgesia in humans using cDNA microarray,” Journal of Physiological Sciences, vol. 56, no. 6, pp. 425–431, 2006. View at Publisher · View at Google Scholar · View at Scopus
  25. S.-T. Kim, W. Moon, Y. Chae, Y. J. Kim, H. Lee, and H.-J. Park, “The effect of electroaucpuncture for 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine-induced proteomic changes in the mouse striatum,” Journal of Physiological Sciences, vol. 60, no. 1, pp. 27–34, 2010. View at Publisher · View at Google Scholar · View at Scopus
  26. S. Jeon, J. K. Youn, S.-T. Kim et al., “Proteomic analysis of the neuroprotective mechanisms of acupuncture treatment in a Parkinson's disease mouse model,” Proteomics, vol. 8, no. 22, pp. 4822–4832, 2008. View at Publisher · View at Google Scholar · View at Scopus
  27. H.-S. Shiue, Y.-S. Lee, C.-N. Tsai, Y.-M. Hsueh, J.-R. Sheu, and H.-H. Chang, “DNA microarray analysis of the effect on inflammation in patients treated with acupuncture for allergic rhinitis,” Journal of Alternative and Complementary Medicine, vol. 14, no. 6, pp. 689–698, 2008. View at Publisher · View at Google Scholar · View at Scopus
  28. C. Tan, J. Wang, W. Feng, W. Ding, and M. Wang, “Preliminary correlation between warm needling treatment for knee osteoarthritis of deficiency-cold syndrome and metabolic functional genes and pathways,” Journal of Acupuncture and Meridian Studies, vol. 3, no. 3, pp. 173–180, 2010. View at Publisher · View at Google Scholar · View at Scopus
  29. X.-Y. Wang, X.-L. Li, S.-Q. Hong, Y.-B. Xi-Yang, and T.-H. Wang, “Electroacupuncture induced spinal plasticity is linked to multiple gene expressions in dorsal root deafferented rats,” Journal of Molecular Neuroscience, vol. 37, no. 2, pp. 97–110, 2009. View at Publisher · View at Google Scholar · View at Scopus
  30. W.-J. Li, S.-Q. Pan, Y.-S. Zeng et al., “Identification of acupuncture-specific proteins in the process of electro-acupuncture after spinal cord injury,” Neuroscience Research, vol. 67, no. 4, pp. 307–316, 2010. View at Publisher · View at Google Scholar · View at Scopus
  31. X. Ding, J. Yu, T. Yu, Y. Fu, and J. Han, “Acupuncture regulates the aging-related changes in gene profile expression of the hippocampus in senescence-accelerated mouse (SAMP10),” Neuroscience Letters, vol. 399, no. 1-2, pp. 11–16, 2006. View at Publisher · View at Google Scholar · View at Scopus
  32. Y. Tang, L. L. Guo, and Q. Zhang, “Effect on electric acupuncture to 1H-NMR spectrogram of senescence accelerated mouse/prone8 kidney,” Journal of Chengdu University of TCM, vol. 32, no. 2, pp. 1–4, 2009. View at Google Scholar
  33. J.-C. Guo, H.-M. Gao, J. Chen et al., “Modulation of the gene expression in the protective effects of electroacupuncture against cerebral ischemia: a cDNA microarray study,” Acupuncture and Electro-Therapeutics Research, vol. 29, no. 3-4, pp. 173–186, 2004. View at Google Scholar · View at Scopus
  34. S. Pan, X. Zhan, X. Su, L. Guo, L. Lv, and B. Su, “Proteomic analysis of serum proteins in acute ischemic stroke patients treated with acupuncture,” Experimental Biology and Medicine, vol. 236, no. 3, pp. 325–333, 2011. View at Publisher · View at Google Scholar · View at Scopus
  35. H. J. Kim, H. J. Park, M. S. Hong et al., “Effect by acupuncture on hypothalamic expression of maternally separated rats: proteomic approach,” Neurological Research, vol. 32, no. 5, pp. 69–73, 2010. View at Google Scholar
  36. Q. F. Wu, S. Mao, C. Wei et al., “Effects of electroacupuncture of Weishu (BL 21) and Zhongwan (CV 12) on serum large molecular metabolites in functional dyspepsia rats,” Acupuncture Research, vol. 35, no. 4, pp. 287–292, 2010. View at Google Scholar
  37. Q. F. Wu, S. Z. Xu, S. G. Yu et al., “Metabonomics and pattern recognition study on the specificity of foot-Yangming Meridian Points,” Shanghai Journal of Acupuncture and Moxibustion, vol. 29, no. 9, pp. 552–555, 2010. View at Google Scholar
  38. Y. F. Luo, Fundamentals of Acupuncture, Sichuan University Press, 2008.
  39. S.-H. Sohn, S. K. Kim, E. Ko et al., “The genome-wide expression profile of electroacupuncture in DNP-KLH immunized mice,” Cellular and Molecular Neurobiology, vol. 30, no. 4, pp. 631–640, 2010. View at Publisher · View at Google Scholar · View at Scopus
  40. Y. Chae, M.-S. Hong, G.-H. Kim et al., “Protein array analysis of cytokine levels on the action of acupuncture in carrageenan-induced inflammation,” Neurological Research, vol. 29, no. 1, pp. S55–S58, 2007. View at Publisher · View at Google Scholar · View at Scopus
  41. S. Y. Zhou, A1H NMR-Based metabonomics study with the Back-Shu and Front-Mu acupoints of Stomach for treating Functional Dyspepsia [M.S. thesis], Chengdu University of Traditional Chinese Medicine, 2011.
  42. Q. F. Wu, A1H NMR-Based metabonomics study on the acupoint specificity effect of Foot-Yangming Meradian in treating Functional Dyspepsia [M.S. thesis], Chengdu University of Traditional Chinese Medicine, 2010.
  43. M. Fan, “Functional Dyspepsia of traditional Chinese medicinal research,” TCM Research, vol. 20, no. 11, pp. 61–64, 2007. View at Google Scholar
  44. F. Zeng, Acupuncture for functional dyspepsia at acipoints on involved meridian: a multi-center, randomized, controlled trial and PETT-CT study [Ph.D. thesis], Chengdu University of Traditional Chinese Medicine, 2010.
  45. L. Guo, Y. Y. Wang, and Z. B. Zhang, “Interpretation of the concept of ZHENG,” Journal of Beijing University of TCM, vol. 26, no. 2, pp. 5–8, 2003. View at Google Scholar
  46. F.-R. Liang, F. Zeng, and Y. Tang, “Thinking about building a clinical syndrome differentiation system of acupuncture and moxibustion,” Chinese Acupuncture & Moxibustion, vol. 28, no. 8, pp. 551–553, 2008. View at Google Scholar · View at Scopus
  47. C. E. Tan, M. Q. Wang, and M. Lu, “Differential gene expression profile of therapeutic effect of warm needling treatment on knee osteoarthritis with kidney-yang deficiency,” Journal of Yunan University of Traditional Chinese Medicine, vol. 34, no. 4, pp. 4–10, 2011. View at Google Scholar
  48. J. H. Yang, H. Y. Cao, Z. K. Feng, and X. Q. Liu, “Epidemiological studies of Traditional Chinese Medicine Syndrome in Primary osteoarthritis,” The Journal of Traditional Chinese Orthopedics and Traumatology, vol. 17, no. 7, pp. 19–22, 2005. View at Google Scholar
  49. Z. Y. Shen, The Sequel of Renal Research, Shanghai science and Technology Press, Shanghai, China, 1990.
  50. H. R. Ding, C. E. Tan, W. Z. Feng, and M. Q. Wang, “Analyse of differentially expressed genes associated with signal transduction of patients who suffered from Osteoarthritis of Deficiency of Kidney-Yang,” Liaoning Journal of Traditional Chinese Medicine, vol. 33, no. 10, pp. 1217–1220, 2006. View at Google Scholar
  51. L. P. Yang, M. C. Wang, M. Q. Wang, and W. G. Liu, “Effect of acupuncture on expression of Immuno-related genes in patients of Kidney-Yang Deficiency Osteoarthritis through gene microarray,” Liaoning Journal of Traditional Chinese Medicine, vol. 33, no. 3, pp. 257–258, 2006. View at Google Scholar
  52. R. Zhang, F. Li, H. Li, H. F. Wang, and Y. H. Song, “Analyzing of point selection features by acupuncture in treatment on Knee Osteoarthritis,” Chinese Journal of Rehabilitation Medicine, vol. 22, no. 4, pp. 357–358, 2007. View at Google Scholar
  53. H. R. Wang and P. X. Li, “Research progress of the relation between stomach theory and Immunity doctrine,” Hunan Journal of Traditional Chinese Medicine, vol. 28, no. 3, pp. 164–165, 2012. View at Google Scholar
  54. L.-P. Yang, M.-C. Wang, W.-G. Liu, and M.-Q. Wang, “Effects of warming-needle therapy on gene expression pathways in the patient with knee osteoarthritis of deficiency-cold syndrome,” Chinese Acupuncture & Moxibustion, vol. 27, no. 9, pp. 677–680, 2007. View at Google Scholar · View at Scopus
  55. J. P. Zhao and S. Chen, “Eligible selection of syndrome differentiation methods based on discrimination and treatment in acupuncture clinic,” Journal of Beijing University of Traditional Chinese Medicine, vol. 19, no. 5, pp. 1–6, 2012. View at Google Scholar
  56. J. Han, “Meridian is a three-dimensional network from bio-electromagnetic radiation interference: an interference hypothesis of meridian,” Cell Biochemistry and Biophysics, vol. 62, no. 2, pp. 297–303, 2012. View at Publisher · View at Google Scholar · View at Scopus
  57. P. Baldi and S. Brunak, Bioinformatics: The Machine Learning Approach, MIT Press, 2nd edition, 2001.
  58. W. Liu, Y. P. Zhu, and F. C. He, “Integration of various “omics” data in biological systems,” Chinese Journal of Biochemistry and Molecular Biology, vol. 23, no. 12, pp. 971–976, 2007. View at Google Scholar
  59. Z. B. Zhang, Y. Y. Wang, A. P. Lv, L. Guo, and Y. Wang, “On combined syndrome differentiation of essential elements of syndrome and syndrome target point corresponding syndromes,” Journal of Traditional Chinese Medicine, vol. 47, no. 7, pp. 483–485, 2006. View at Google Scholar
  60. T. Ideker, V. Thorsson, J. A. Ranish et al., “Integrated genomic and proteomic analyses of a systematically perturbed metabolic network,” Science, vol. 292, no. 5518, pp. 929–934, 2001. View at Publisher · View at Google Scholar · View at Scopus