Metabolism of Genipin in Rat and Identification of Metabolites by Using Ultraperformance Liquid Chromatography/Quadrupole Time-of-Flight Tandem Mass Spectrometry

Table 3

The metabolites in different biological samples of rats.

	Formula	Bile	Urine	Plasma*	Feces	Plasma**
G0	C11H14O5 (genipin)	−	−	−	−	−
G1	C17H22O11	+	+	+	−	+
G2	C11H14SO8	+	+	+	+	−
G3	C17H24O11	+	+	−	−	−
G4	C16H20O11	+	−	−	−	−
G5	C13H17NO6S	+	+	−	−	−
G6	C11H12O5	+	−	−	−	−
G7	C13H17NO8S	+	+	−	−	−
G8	C13H17NO9S	+	−	−	−	−
G9	C16H22N2O7	+	+	−	−	−
G10	C16H24O9	+	−	−	−	−

+: found; −: not found.
Plasma* were from rats given single dose of genipin solution at 50 mg/kg of body weight by gavage into the stomach.
Plasma** were from rats given single dose of genipin solution at 10 mg/kg of body weight by intravenous administration.