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Evidence-Based Complementary and Alternative Medicine
Volume 2013, Article ID 957078, 13 pages
http://dx.doi.org/10.1155/2013/957078
Research Article

Zuo Jin Wan, a Traditional Chinese Herbal Formula, Reverses P-gp-Mediated MDR In Vitro and In Vivo

1Department of Medical Oncology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
2Interventional Cancer Institute of Integrative Medicine & Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China
3Department of Biomedical Sciences, Cornell University, Ithaca, NY 14850, USA
4Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
5Department of Chemistry, University of South Florida, Tampa, FL 33620, USA

Received 16 December 2012; Accepted 29 January 2013

Academic Editor: Pradeep Visen

Copyright © 2013 Hua Sui et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. H. Sui, S. Zhou, Y. Wang et al., “COX-2 contributes to P-glycoprotein-mediated multidrug resistance via phosphorylation of c-Jun at Ser63/73 in colorectal cancer,” Carcinogenesis, vol. 32, no. 5, pp. 667–675, 2011. View at Publisher · View at Google Scholar · View at Scopus
  2. H. Sui, Z. Z. Fan, and Q. Li, “Signal transduction pathways and transcriptional mechanisms of ABCB1/Pgp-mediated multiple drug resistance in human cancer cells,” Journal of International Medical Research, vol. 40, no. 2, pp. 426–435, 2012. View at Google Scholar · View at Scopus
  3. H. Sui, L. Zhou, P. Yin et al., “JNK signal transduction pathway regulates MDR1/ p-glycoprotein-mediated multi drug resistance in colon carcinoma cells,” World Chinese Journal of Digestology, vol. 19, no. 9, pp. 892–898, 2011. View at Google Scholar · View at Scopus
  4. G. An, F. Wu, and M. E. Morris, “5,7-Dimethoxyflavone and multiple flavonoids in combination alter the ABCG2-mediated tissue distribution of mitoxantrone in mice,” Pharmaceutical Research, vol. 28, no. 5, pp. 1090–1099, 2011. View at Publisher · View at Google Scholar · View at Scopus
  5. A. J. Slot, S. V. Molinski, and S. P. Cole, “Mammalian multidrug-resistance proteins (MRPs),” Essays in Biochemistry, vol. 50, no. 1, pp. 179–207, 2011. View at Google Scholar
  6. S. M. He, R. Li, J. R. Kanwar, and S. F. Zhou, “Structural and functional properties of human multidrug resistance protein 1 (MRP1/ABCC1),” Current Medicinal Chemistry, vol. 18, no. 3, pp. 439–481, 2011. View at Google Scholar · View at Scopus
  7. K. Taniguchi, M. Wada, K. Kohno et al., “A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation,” Cancer Research, vol. 56, no. 18, pp. 4124–4129, 1996. View at Google Scholar · View at Scopus
  8. I. Cascorbi and S. Haenisch, “Pharmacogenetics of ATP-binding cassette transporters and clinical implications,” Methods in Molecular Biology, vol. 596, pp. 95–121, 2010. View at Google Scholar · View at Scopus
  9. A. Saglam, M. Hayran, and A. H. Uner, “Immunohistochemical expression of multidrug resistance proteins in mature T/NK-cell lymphomas,” APMIS, vol. 116, no. 9, pp. 791–800, 2008. View at Publisher · View at Google Scholar · View at Scopus
  10. W. Q. Hu, C. W. Peng, and Y. Li, “The expression and significance of P-glycoprotein, lung resistance protein and multidrug resistance-associated protein in gastric cancer,” Journal of Experimental & Clinical Cancer Research, vol. 28, p. 144, 2009. View at Google Scholar
  11. W. Li, S. Chan, D. Guo, M. Chung, T. Leung, and P. H. Yu, “Water extract of Rheum officinale Baill. induces apoptosis in human lung adenocarcinoma A549 and human breast cancer MCF-7 cell lines,” Journal of Ethnopharmacology, vol. 124, no. 2, pp. 251–256, 2009. View at Publisher · View at Google Scholar · View at Scopus
  12. A. Rasul, B. Yu, L. Yang et al., “Induction of mitochondria-mediated apoptosis in human gastric adenocarcinoma SGC-7901 cells by kuraridin and nor-kurarinone isolated from sophora flavescens,” Asian Pacific Journal of Cancer Prevention, vol. 12, no. 10, pp. 2499–2504, 2011. View at Google Scholar · View at Scopus
  13. Q. Li, H. Sui, X. Liu, J. M. Qin, P. H. Yin, and Z. Z. Fan, “Reversal effect of Jianpi Jiedu Recioe on JNK/SAPK signal transduction pathway-mediated multidrug resistance in human colon carcinoma cells,” CJTCMP, vol. 27, no. 3, pp. 731–735, 2012. View at Google Scholar
  14. Y. D. Min, M. C. Yang, K. H. Lee, K. R. Kim, S. U. Choi, and K. R. Lee, “Protoberberine alkaloids and their reversal activity of P-gp expressed multidrug resistance (MDR) from the rhizome of Coptis japonica Makino,” Archives of Pharmacal Research, vol. 29, no. 9, pp. 757–761, 2006. View at Google Scholar
  15. C. He, R. Rong, J. Liu, J. Wan, K. Zhou, and J. X. Kang, “Effects of Coptis extract combined with chemotherapeutic agents on ROS production, multidrug resistance, and cell growth in A549 human lung cancer cells,” Chinese Medicine, vol. 7, no. 1, article 11, 2012. View at Publisher · View at Google Scholar
  16. J. Yang, L. Wu, S. Tashino, S. Onodera, and T. Ikejima, “Critical roles of reactive oxygen species in mitochondrial permeability transition in mediating evodiamine-induced human melanoma A375-S2 cell apoptosis,” Free Radical Research, vol. 41, no. 10, pp. 1099–1108, 2007. View at Publisher · View at Google Scholar · View at Scopus
  17. X. N. Wang, X. Han, L. N. Xu et al., “Enhancement of apoptosis of human hepatocellular carcinoma SMMC-7721 cells through synergy of berberine and evodiamine,” Phytomedicine, vol. 15, no. 12, pp. 1062–1068, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. Z. G. Yang, A. Q. Chen, and B. Liu, “Antiproliferation and apoptosis induced by evodiamine in human colorectal carcinoma cells (COLO-205),” Chemistry & Biodiversity, vol. 6, no. 6, pp. 924–933, 2009. View at Google Scholar
  19. F. R. Zhao, H. P. Mao, H. Zhang et al., “Antagonistic effects of two herbs in Zuojin Wan, a traditional Chinese medicine formula, on catecholamine secretion in bovine adrenal medullary cells,” Phytomedicine, vol. 17, no. 8-9, pp. 659–668, 2010. View at Publisher · View at Google Scholar · View at Scopus
  20. K. Kolinsky, B. Shen, Y. Zhang et al., “In vivo activity of novel capecitabine regimens alone and with bevacizumab and oxaliplatin in colorectal cancer xenograft models,” Molecular Cancer Therapeutics, vol. 8, no. 1, pp. 75–82, 2009. View at Publisher · View at Google Scholar · View at Scopus
  21. Y. Mi, Y. Liang, H. Huang et al., “Apatinib (YN968D1) reverses multidrug resistance by inhibiting the efflux function of multiple ATP-binding cassette transporters,” Cancer Research, vol. 70, no. 20, pp. 7981–7991, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. Q. F. Tang, X. Liu, Y. Ge et al., “Experimental study on inhibiting proliferation and inducing apoptosis of zuo jin wan alcohol extracts on human gastric cancer cells infected by Helicobacter pylori,” Chongqing Medicine, vol. 41, no. 15, pp. 1462–1464, 2012. View at Google Scholar
  23. H. Sui, L. H. Zhou, X. Liu et al., “COX-2 regulate MDR1/P-glycoprotein-mediated multidrug resistance in colon carcinoma cells,” China Oncology, vol. 21, no. 4, pp. 241–246, 2011. View at Google Scholar
  24. H. Yang, M. Hua, H. Liu et al., “An epirubicin-conjugated nanocarrier with MRI function to overcome lethal multidrug-resistant bladder cancer,” Biomaterials, vol. 33, no. 15, pp. 3919–3930, 2012. View at Publisher · View at Google Scholar · View at Scopus
  25. F. Wang, Y. J. Mi, X. G. Chen et al., “Axitinib targeted cancer stemlike cells to enhance efficacy of chemotherapeutic drugs via inhibiting the drug transport function of ABCG2,” Molecular Medicine, vol. 18, no. 1, pp. 887–898, 2012. View at Google Scholar
  26. K. J. Liu, J. H. He, X. D. Su et al., “Saracatinib (AZD0530) is a potent modulator of ABCB1-mediated multidrug resistance in vitro and in vivo,” Journal of Cancer, vol. 132, no. 1, pp. 224–235, 2013. View at Google Scholar
  27. H. Sui, B. H. Jin, P. H. Yin, Z. Z. Fan, and Q. Li, “Reversal effect of Jianpi Jiedu Recioe on multidrug resistance in human colon carcinoma cells,” Chinese Journal of Experimental Traditional Medical Formulae, vol. 18, no. 9, pp. 181–185, 2012. View at Google Scholar
  28. X. Wang, L. Xu, J. Peng, K. Liu, L. Zhang, and Y. Zhang, “In vivo inhibition of s180 tumors by the synergistic effect of the chinese medicinal herbs coptis chinensis and evodia rutaecarpa,” Planta Medica, vol. 75, no. 11, pp. 1215–1220, 2009. View at Publisher · View at Google Scholar · View at Scopus
  29. L. J. Ostruszka and D. S. Shewach, “The role of cell cycle progression in radiosensitization by 2′,2′-difluoro-2′-deoxycytidine,” Cancer Research, vol. 60, no. 21, pp. 6080–6088, 2000. View at Google Scholar · View at Scopus
  30. J. Gao, T. He, Y. Li, and Y. Wang, “A traditional chinese medicine formulation consisting of Rhizoma corydalis and Rhizoma curcumae exerts synergistic anti-tumor activity,” Oncology Reports, vol. 22, no. 5, pp. 1077–1083, 2009. View at Publisher · View at Google Scholar · View at Scopus
  31. Y. Wang, Z. Yang, and X. Zhao, “Honokiol induces paraptosis and apoptosis and exhibits schedule-dependent synergy in combination with imatinib in human leukemia cells,” Toxicology Mechanisms and Methods, vol. 20, no. 5, pp. 234–241, 2010. View at Publisher · View at Google Scholar · View at Scopus
  32. Z. Chen, M. Ingouff, V. Sundaresan, and F. Berger, “Chromatin assembly factor 1 regulates the cell cycle but not cell fate during male gametogenesis in Arabidopsis thaliana,” Development, vol. 135, no. 1, pp. 65–73, 2008. View at Publisher · View at Google Scholar · View at Scopus
  33. V. S. Romanov, M. V. Abramova, S. B. Svetlikova et al., “p21Waf1 is required for cellular senescence but not for cell cycle arrest induced by the HDAC inhibitor sodium butyrate,” Cell Cycle, vol. 9, no. 19, pp. 3945–3955, 2010. View at Publisher · View at Google Scholar · View at Scopus
  34. P. Mistry, A. J. Stewart, W. Dangerfield et al., “In vitro and in vivo reversal of P-glycoprotein-mediated multidrug resistance by a novel potent modulator, XR9576,” Cancer Research, vol. 61, no. 2, pp. 749–758, 2001. View at Google Scholar · View at Scopus
  35. D. Chao, L. Lin, S. Kao et al., “Inhibitory effects of Zuo-Jin-Wan and its alkaloidal ingredients on activator protein 1, nuclear factor-κB, and cellular transformation in HepG2 cells,” Fitoterapia, vol. 82, no. 4, pp. 749–758, 2011. View at Publisher · View at Google Scholar · View at Scopus