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Evidence-Based Complementary and Alternative Medicine
Volume 2013 (2013), Article ID 960603, 11 pages
http://dx.doi.org/10.1155/2013/960603
Research Article

Modulation of the Expression of the Proinflammatory IL-8 Gene in Cystic Fibrosis Cells by Extracts Deriving from Olive Mill Waste Water

1Department of Life Science and Biotechnology, Laboratory of Medicinal and Molecular Biotechnology, University of Ferrara, Via Fossato di Mortara 74, 44121 Ferrara, Italy
2Health Products Laboratory, University of Ferrara, Via Fossato di Mortara 17/19, 44121 Ferrara, Italy

Received 7 February 2013; Revised 22 April 2013; Accepted 29 April 2013

Academic Editor: Chong-Zhi Wang

Copyright © 2013 Ilaria Lampronti et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. J. Welsh, L. C. Tsui, T. F. Boat, and A. L. Beaudet, “Cystic fibrosis,” in The Metabolic and Molecular Bases of Inherited Disease, C. R. Scriver, A. L. Beaudet, W. S. Sly, and D. Valle, Eds., pp. 3799–3876, McGraw-Hill, New York, NY, USA, 1995. View at Google Scholar
  2. M. N. Becker, M. S. Sauer, M. S. Muhlebach et al., “Cytokine secretion by cystic fibrosis airway epithelial cells,” American Journal of Respiratory and Critical Care Medicine, vol. 169, no. 5, pp. 645–653, 2004. View at Google Scholar · View at Scopus
  3. H. R. Black, J. R. Yankaskas, L. G. Johnson, and T. L. Noah, “Interleukin-8 production by cystic fibrosis nasal epithelial cells after tumor necrosis factor-α and respiratory syncytial virus stimulation,” American Journal of Respiratory Cell and Molecular Biology, vol. 19, no. 2, pp. 210–215, 1998. View at Google Scholar · View at Scopus
  4. T. L. Bonfield, J. R. Panuska, M. W. Konstan et al., “Inflammatory cytokines in cystic fibrosis lungs,” American Journal of Respiratory and Critical Care Medicine, vol. 152, no. 6 I, pp. 2111–2118, 1995. View at Google Scholar · View at Scopus
  5. G. E. Carpagnano, P. J. Barnes, D. M. Geddes, M. E. Hodson, and S. A. Kharitonov, “Increased leukotriene B4 and interleukin-6 in exhaled breath condensate in cystic fibrosis,” American Journal of Respiratory and Critical Care Medicine, vol. 167, no. 8, pp. 1109–1112, 2003. View at Publisher · View at Google Scholar · View at Scopus
  6. A. Tamanini, M. Borgatti, A. Finotti et al., “Trimethylangelicin reduces IL-8 transcription and potentiates CFTR function,” American Journal of Physiology, vol. 300, no. 3, pp. L380–L390, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. E. Nicolis, I. Lampronti, M. C. Dechecchi et al., “Modulation of expression of IL-8 gene in bronchial epithelial cells by 5-methoxypsoralen,” International Immunopharmacology, vol. 9, no. 12, pp. 1411–1422, 2009. View at Publisher · View at Google Scholar · View at Scopus
  8. E. Nicolis, I. Lampronti, M. C. Dechecchi et al., “Pyrogallol, an active compound from the medicinal plant Emblica officinalis, regulates expression of pro-inflammatory genes in bronchial epithelial cells,” International Immunopharmacology, vol. 8, no. 12, pp. 1672–1680, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. A. Taamalli, D. Arráez-Román, M. Zarrouk, J. Valverde, A. Segura-Carretero, and A. Fernández-Gutiérrez, “The occurrence and bioactivity of polyphenols in Tunisian olive products and by-products: a review,” Journal of Food Science, vol. 77, no. 4, pp. 83–92, 2012. View at Google Scholar
  10. M. Borgatti, A. Chilin, L. Piccagli et al., “Development of a novel furocoumarin derivative inhibiting NF-kappaB dependent biological functions: design, synthesis and biological effects,” European Journal of Medicinal Chemistry, vol. 46, no. 10, pp. 4870–4877, 2011. View at Google Scholar
  11. S. Luqman and J. M. Pezzuto, “NFκB: a promising target for natural products in cancer chemoprevention,” Phytotherapy Research, vol. 24, no. 7, pp. 949–963, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. A. Mantovani, F. Marchesi, C. Porta, P. Allavena, and A. Sica, “Linking inflammation reactions to cancer: novel targets for therapeutic strategies,” Advances in Experimental Medicine and Biology, vol. 610, pp. 112–127, 2008. View at Publisher · View at Google Scholar · View at Scopus
  13. G. Sethi, B. Sung, and B. B. Aggarwal, “Nuclear factor-κB activation: from bench to bedside,” Experimental Biology and Medicine, vol. 233, no. 1, pp. 21–31, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. O. Ramström, K. Skudar, J. Haines, P. Patel, and O. Brüggemann, “Food analyses using molecularly imprinted polymers,” Journal of Agriculture and Food Chemistry, vol. 49, no. 5, pp. 2105–2114, 2001. View at Google Scholar
  15. C. Michailof, P. Manesiotis, and C. Panayiotou, “Synthesis of caffeic acid and p-hydroxybenzoic acid molecularly imprinted polymers and their application for the selective extraction of polyphenols from olive mill waste waters,” Journal of Chromatography A, vol. 1182, no. 1, pp. 25–33, 2008. View at Publisher · View at Google Scholar · View at Scopus
  16. R. C. Boucher, “New concepts of the pathogenesis of cystic fibrosis lung disease,” European Respiratory Journal, vol. 23, no. 1, pp. 146–158, 2004. View at Publisher · View at Google Scholar · View at Scopus
  17. T. Z. Khan, J. S. Wagener, T. Bost, J. Martinez, F. J. Accurso, and D. W. H. Riches, “Early pulmonary inflammation in infants with cystic fibrosis,” American Journal of Respiratory and Critical Care Medicine, vol. 151, no. 4, pp. 1075–1082, 1995. View at Google Scholar · View at Scopus
  18. V. Bezzerri, M. Borgatti, A. Finotti, A. Tamanini, R. Gambari, and G. Cabrini, “Mapping the transcriptional machinery of the IL-8 gene in human bronchial epithelial cells,” The Journal of Immunology, vol. 187, no. 11, pp. 6069–6081, 2011. View at Google Scholar
  19. I. Lampronti, N. Bianchi, M. Borgatti et al., “Effects of vanadium complexes on cell growth of human leukemia cells and protein-DNA interactions,” Oncology Reports, vol. 14, no. 1, pp. 9–15, 2005. View at Google Scholar · View at Scopus
  20. M. Borgatti, R. Rizzo, M. B. Dal Canto et al., “Release of sICAM-1 in oocytes and in vitro fertilized human embryos,” PLoS ONE, vol. 3, no. 12, Article ID e3970, 2008. View at Publisher · View at Google Scholar · View at Scopus
  21. L. Penolazzi, E. Lambertini, E. Tavanti et al., “Evaluation of chemokine and cytokine profiles in osteoblast progenitors from umbilical cord blood stem cells by BIO-PLEX technology,” Journal of Clinical Investigation, vol. 107, no. 1, pp. 3–6, 2001. View at Google Scholar
  22. V. Bezzerri, M. Borgatti, E. Nicolis et al., “Transcription factor oligodeoxynucleotides to NF-κB inhibit transcription of IL-8 in bronchial cells,” American Journal of Respiratory Cell and Molecular Biology, vol. 39, no. 1, pp. 86–96, 2008. View at Publisher · View at Google Scholar · View at Scopus
  23. R. Gambari Roberto, M. Borgatti, V. Bezzerri et al., “Decoy oligodeoxyribonucleotides and peptide nucleic acids-DNA chimeras targeting nuclear factor kappa-B: inhibition of IL-8 gene expression in cystic fibrosis cells infected with Pseudomonas aeruginosa,” Biochemical Pharmacology, vol. 80, no. 12, pp. 1887–1894, 2010. View at Publisher · View at Google Scholar · View at Scopus
  24. G. Marzaro, A. Guiotto, M. Borgatti et al., “Psoralen derivatives as inhibitors of nf-kappab/dna interaction: synthesis, molecular modeling, 3d-qsar, and biological evaluation,” Journal of Medicinal Chemistry, vol. 14, no. 56, pp. 1830–1842, 2013. View at Google Scholar
  25. R. Gambari, M. Borgatti, I. Lampronti et al., “Corilagin is a potent inhibitor of NF-kappaB activity and downregulates TNF-alpha induced expression of IL-8 gene in cystic fibrosis IB3-1 cells,” International Immunopharmacology, vol. 13, no. 3, pp. 308–315, 2012. View at Google Scholar
  26. M. Borgatti, A. Chilin, L. Piccagli et al., “Development of a novel furocoumarin derivative inhibiting NF-kappaB dependent biological functions: design, synthesis and biological effects,” European Journal of Medicinal Chemistry, vol. 46, no. 10, pp. 4870–4877, 2011. View at Google Scholar
  27. J. Fuchs and R. Milbradt, “Skin anti-inflammatory activity of apigenin-7-glucoside in rats,” Arzneimittel-Forschung, vol. 43, no. 3, pp. 370–372, 1993. View at Google Scholar · View at Scopus
  28. N. P. Seeram, L. D. Bourquin, and M. G. Nair, “Degradation products of cyanidin glycosides from tart cherries and their bioactivities,” Journal of Agricultural and Food Chemistry, vol. 49, no. 10, pp. 4924–4929, 2001. View at Publisher · View at Google Scholar · View at Scopus
  29. R. Sasaki, N. Nishimura, H. Hoshino et al., “Cyanidin 3-glucoside ameliorates hyperglycemia and insulin sensitivity due to downregulation of retinol binding protein 4 expression in diabetic mice,” Biochemical Pharmacology, vol. 74, no. 11, pp. 1619–1627, 2007. View at Publisher · View at Google Scholar · View at Scopus
  30. A. C. Muñoz-Espada and B. A. Watkins, “Cyanidin attenuates PGE2 production and cyclooxygenase-2 expression in LNCaP human prostate cancer cells,” Journal of Nutritional Biochemistry, vol. 17, no. 9, pp. 589–596, 2006. View at Publisher · View at Google Scholar · View at Scopus
  31. S. W. Min, S. N. Ryu, and D. H. Kim, “Anti-inflammatory effects of black rice, cyanidin-3-O-β-d-glycoside, and its metabolites, cyanidin and protocatechuic acid,” International Immunopharmacology, vol. 10, no. 8, pp. 959–966, 2010. View at Publisher · View at Google Scholar · View at Scopus
  32. O. H. Kang, J. H. Lee, and D. Y. Kwon, “Apigenin inhibits release of inflammatory mediators by blocking the NF-κB activation pathways in the HMC-1 cells,” Immunopharmacology and Immunotoxicology, vol. 33, no. 3, pp. 473–479, 2011. View at Publisher · View at Google Scholar · View at Scopus
  33. L. L. Pang, R. R. Li, and L. F. Zhou, “Inhibitory effects of apigenin on the expression of GATA-3 and Th2 cytokines in asthmatic mice,” Zhongguo Zhong Xi Yi Jie He Za Zhi, vol. 30, no. 4, pp. 383–387, 2010. View at Google Scholar
  34. R. R. Li, L. L. Pang, Q. Du, Y. Shi, W. J. Dai, and K. S. Yin, “Apigenin inhibits allergen-induced airway inflammation and switches immune response in a murine model of asthma,” Immunopharmacology and Immunotoxicology, vol. 32, no. 3, pp. 364–370, 2010. View at Publisher · View at Google Scholar · View at Scopus
  35. C. Nicholas, S. Batra, M. A. Vargo et al., “Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-κB through the suppression of p65 phosphorylation,” Journal of Immunology, vol. 179, no. 10, pp. 7121–7127, 2007. View at Google Scholar · View at Scopus
  36. B. A. Abdulrahman, A. A. Khweek, A. Akhter et al., “Autophagy stimulation by rapamycin suppresses lung inflammation and infection by Burkholderia cenocepacia in a model of cystic fibrosis,” Autophagy, vol. 7, no. 11, pp. 1359–1370, 2011. View at Google Scholar
  37. M. Sabet, C. E. Miller, T. G. Nolan, K. Senekeo-Effenberger, M. N. Dudley, and D. C. Griffith, “Efficacy of aerosol MP-376, a levofloxacin inhalation solution, in models of mouse lung infection due to Pseudomonas aeruginosa,” Antimicrobial Agents and Chemotherapy, vol. 53, no. 9, pp. 3923–3928, 2009. View at Publisher · View at Google Scholar · View at Scopus
  38. N. Hoffmann, B. Lee, M. Hentzer et al., “Azithromycin blocks quorum sensing and alginate polymer formation and increases the sensitivity to serum and stationary-growth-phase killing of Pseudomonas aeruginosa and attenuates chronic P. aeruginosa lung infection in Cftr(-/-) mice,” Antimicrobial Agents and Chemotherapy, vol. 51, no. 10, pp. 3677–3687, 2007. View at Publisher · View at Google Scholar · View at Scopus
  39. J. Wang, Y. Liao, J. Fan, T. Ye, X. Sun, and S. Dong, “Apigenin inhibits the expression of IL-6, IL-8, and ICAM-1 in DEHP-stimulated human umbilical vein endothelial cells and in vivo,” Inflammation, vol. 35, no. 4, pp. 1466–1476, 2012. View at Google Scholar
  40. B. Illek and H. Fischer, “Flavonoids stimulate Cl conductance of human airway epithelium in vitro and in vivo,” American Journal of Physiology, vol. 275, no. 5, pp. L902–L910, 1998. View at Google Scholar · View at Scopus
  41. M. Lim, K. McKenzie, A. D. Floyd, E. Kwon, and P. L. Zeitlin, “Modulation of ΔF508 cystic fibrosis transmembrane regulator trafficking and function with 4-phenylbutyrate and flavonoids,” American Journal of Respiratory Cell and Molecular Biology, vol. 31, no. 3, pp. 351–357, 2004. View at Publisher · View at Google Scholar · View at Scopus