Antiepileptic Effect of <i>Uncaria rhynchophylla</i> and <i>Rhynchophylline</i> Involved in the Initiation of c-Jun N-Terminal Kinase Phosphorylation of MAPK Signal Pathways in Acute Seizures of Kainic Acid-Treated Rats

<table>Effect of UR and RP on IL-6 in KA-induced epileptic seizures in rats. The IL-6 levels were lower in the cerebral cortex (Cortex) brain tissue for Groups KA, PK, UR, and VA than those in Group N. The IL-6 levels in the hippocampus (Hippocampus) brain tissue for Group UR were lower than those in Group N (N, normal group; KA, KA/control group; PK, PK group; UR, UR group; RP, RP group; VA, VA group). JNK: *<i>P</i> &lt; .05, ***<i>P</i>  &lt; .001 compared with N.</table>

Evidence-Based Complementary and Alternative Medicine

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Figure 4

Figure 4: Antiepileptic Effect of <i>Uncaria rhynchophylla</i> and <i>Rhynchophylline</i> Involved in the Initiation of c-Jun N-Terminal Kinase Phosphorylation of MAPK Signal Pathways in Acute Seizures of Kainic Acid-Treated Rats 

Figure 4 | Antiepileptic Effect of Uncaria rhynchophylla and Rhynchophylline Involved in the Initiation of c-Jun N-Terminal Kinase Phosphorylation of MAPK Signal Pathways in Acute Seizures of Kainic Acid-Treated Rats 